Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 56-61


Significance of interleukin-1 and interleukin-2 in pathogeny ofsystemic scleroderma

Ye.M.Neyko R.I.Yatsyshyn

    Ivano-Frankivsk Medical Academy


Abstract

The purpose of a research was to define the levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) in patients with systemic scleroderma (SSc) and to analyse their dependence on the course of the illness. 75 paticnts with SSc and 20 apparently healthy people were examined. Besides the well-known clinical-biochemical and instrumental investigations, the levels of IL-1 and Il-2 in all the patients were determined in serum with an immunoenzymatic method using a set of reactants Pro Con IL-1b and Pro Con IL-2 (Russia). The data obtained give evidence for an increase in both IL-1 and IL-2 levels. As the correlation between the level of IL-1 and the acuteness of the pathological process has been shown to be especially distinct, it can be used for marking an acute form of this pathology. Thus, both parametres (IL-1, IL-2) depend on the acuity and peculiarities of SSc, and on the concomitant damage of the internal organs. The most pronounced increase in LL-2 level has been observed at visceralisation of SSc.

References

  1. Возианов А.Ф., Бутенко А.К., Зак А.П. Цитокины: биологические и противоопухолевые средства.-К.: Наук. думка, 1998. - 314 с.
  2. Гусева Н.Г. Системная склеродермия и псевдосклеродермические синдромы. - М.:Медицина,1993. - 268 с.
  3. Дранник Г.Н. Клиническая иммунология и аллергология. - Одесса: Астропринт, 1999. - 604 c.
  4. Клиническая иммунология и аллергология / Подред.Л.Йегера.-2-е изд.:Пер.с нем. - М.:Медицина, 1990. - Т. 2. - 345 с.
  5. Нейко Є.М., Александрук О.Д., Островський М.М. Фізіологія цитокінів // Галицьк. лікар.вісник. - 2000. - 7, № 4. - C.153-158.
  6. Ревматические болезни / Руководство для врачей / Под ред. В.А.Насоновой, Н.В.Бунчука. -М.: Медицина,1997. - 520 с.
  7. Needleman BW, Wigley FM, Stair RW. Interleukin-1,interleukin-2, interleukin-4, interleukin-6, tumornecrosis factor alpha, and interferon-gamma levels in sera from patients with scleroderma //Arthritis Rheum.-1992. - 35, N 1. - P.67-72.
  8. Needleman BW. Immunologic aspects of scleroderma// Curr. Opin. Rheumatol. - 1992. - 4, N 6. -P.862-868.
  9. 9. Rubin L.A. The soluble interleukin-2 receptor in rheumatic disease // Arthr.Rheum. - 1990. - 33.- P.1145-1148.
  10. 10. Smith EA. Connective tissue metabolism including cytokines in scleroderma. // Curr. Opin. Rheumatol. - 1992. - 4, N 6. - P.869-877.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.