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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 56-61

Significance of interleukin-1 and interleukin-2 in pathogeny ofsystemic scleroderma

Ye.M.Neyko R.I.Yatsyshyn

    Ivano-Frankivsk Medical Academy



Abstract

The purpose of a research was to define the levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) in patients with systemic scleroderma (SSc) and to analyse their dependence on the course of the illness. 75 paticnts with SSc and 20 apparently healthy people were examined. Besides the well-known clinical-biochemical and instrumental investigations, the levels of IL-1 and Il-2 in all the patients were determined in serum with an immunoenzymatic method using a set of reactants Pro Con IL-1b and Pro Con IL-2 (Russia). The data obtained give evidence for an increase in both IL-1 and IL-2 levels. As the correlation between the level of IL-1 and the acuteness of the pathological process has been shown to be especially distinct, it can be used for marking an acute form of this pathology. Thus, both parametres (IL-1, IL-2) depend on the acuity and peculiarities of SSc, and on the concomitant damage of the internal organs. The most pronounced increase in LL-2 level has been observed at visceralisation of SSc.

Full text: (PDF, in Ukrainian)

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