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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2010; 56(1): 127-142

MOLECULAR AND CELLULAR MECHANISMS OF ALZHEIMER’S DISEASE DEVELOPMENT

E.P. Kostyuk, T.Y. Korol, P.G. Kostyuk

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz56.01.127


Abstract

Neuropathological studies classified several neurodegenerative illnesses among which Alzheimer’s and Parkinson’s diseases are the most frequent. Alzheimer’s disease is characterized by the presence of cognitive syndromes and almost complete destruction of memory. It is suggested that the basis of these syndromes is formation of senile plaques the main component of which is β-amyloid-42 peptide (mainly in hippocampal neurons), changes in calcium homeostasis and synaptic plasticity. Recent data indicate that alterations of calcium homeostasis connected with changes in neuronal membrane and functioning of the endoplasmic reticulum and leads to changes in long-term potentiation and long-term depression. Therefore the task of this review was the analysis of alterations in the functioning of structures involved in calcium homeostasis (including mitochondria, endoplasmic reticulum, calcium channels) as well as processes leading to changes in synaptic plasticity. Beside this we intend to clarify (mainly from the data of literature) which process is the most ponderable in the development of Alzheimer’s disease.

Keywords: Alzheimer’s disease, amyloid, calcium homeostasis, synaptic plasticity, mitochondria, endoplasmic reticulum, calcium channels.

Full text: (PDF, in Ukrainian)

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