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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 50-55


The brain energetic metabolism disorders in bemegride-kindledrabbits

A.P.Cherchenko I.N.Todor

    Institute of Neurosurgery A.P.Romodanov AMSU,Kiev



Abstract

Changes in the energetic metabolism in the cortex were examined in bemegride-kindled rabbits. A reliable decrease in the ATP and an increase in the AMP contents in the cortical tissues as well as low ATP/AMP and energetic charge coefficients have been found after kindling the rabbits for 14 and 30-days as compared to the control groups of animals. Considerable disorders in the oxidative phosphorilation in the mitochondria of the cortical tissues have been determined after the succinate and glutamate oxidation: a decrease in the oxygen utilization rate at V3 active metabolic state, lowering the respiratory control coefficient and the disscociation between phosphorilation and oxidation. Those desorders were more expressed after glutamate oxidation as compared to a succinate one. In addition, it has been determined that oxygen utilization at V2 state was reliably decreased; both coefficient of energetic production and ATP-ase reserve activity lowered.

References

  1. Захарова Н.Б., Рубин В.И. Тонкослойная хроматография нуклеотидов эритроцитов на пластинках силуфол // Лаб. дело. – 1980. - № 12. –С.735-758.
  2. Каминский Ю.Г. Суточные ритмы в метаболизме. -Пушино: ОНТИ НЦБИ АН СССР, 1987. –193 с.
  3. Погодаев К.И. Эпилептология и патохимия мозга.- М.:Медицина, 1986. – 285 с.
  4. Черченко А.П., Шамаєв М.І., Нагорний Є.А. та ін. Вплив хронічного внутрішнього опромінення малими дозами цезію-137 на функціональний стан ЦНС лабораторних тварин та їх нащадків.– В кн.: Хронічний вплив малих доз опромінення на нервову систему. – К.: Чорнобильінтерінформ, 1998. - С.208-224.
  5. Черченко А.П., Шмєльова Г.А., Ритікова Л.С.Ультраструктурні зміни в гіпокампі і сенсомо торній корі кроликів при епілептогенних впливах //Вісн. Київ.ун-ту Проблеми регуляції фізіол. функцій. – 1994. – Вип.1. – С.93-99.
  6. Франк Г.М., Кондрашова Е.И. Мохова Е.И. Руководство по изучению биологического окисления полярографическим методом. - М.: Наука,1973 – 221 с
  7. Chapman A.G. Glutamate and epilepsy // J. Nutr.– 2000. – 130, N 4. – Р. 1043-1045.
  8. Graeber M.B., Muller U. Recent developments in the molecular genetics of mitochondrial disorders //J. Neurol. Sci. – 1998. – 153, №2. – P.251-263. 11.
  9. 9. Kristal B.S., Chen J.J. Sensitivity of mitochondrialtranscription to different free radical species //Free Radical Biol. – 1994. – 16. – P. 323-329.
  10. 10. Kunz W.S., Goussakov I.V., Beck H., Elger C.E.Altered mitochondrial oxidative phosphorylation in hippocampal slice of kainate-trated rats //Brain Res. – 1999. – 826, №2. – P.236-242.
  11. Li Z., Yamamoto T., Ono J. et al. The effect of pentilenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortexof rats // Neurosci. Lett. – 2000. – 282, N 1-2. –P.117-119.
  12. Lowry O.H., Rosebough N.I., Farr A.L., Rantall R.J. Protein measurement with the Folin phenol reagent //J. Biol. Chem. – 1951. – 193, № 1. –P.265-275.
  13. Mc Namara J.O. Identification of Genetic Defect of an Epilepsy: Strategies for Therapeutic Advances //Epilepsia. – 1994. – Suppl. 1. – P.51-57.
  14. Riedel G., Wetzel W., Reymann K.G. Comparing the role of metabotropic glutamate receptors in long-term potentiation, learning and memory //Prog. Neuropsychopharmacol. Biol. Psychiatry. –1996. – 20. – P.761-787.
  15. Schuelke M., Bakker M., Stoltenburg G. et al. Epilepsia partialis continua associated with a homoplasmic mitochondrial tRNA (Ser)YCN mutation //Ann. Neurol. – 1998. – 44, №4. – P.700-704.
  16. Todor I.N., Chekhun V.F. The respiration of mitochondria from the liver of rats treated with cisplatinum and millimeter range electromagnetic radiation // Exp. Oncol. – 1995. – 17, № 4. –P.137-140.
  17. Torbersen T., Mathiesen E., Aasly J. Epilepsy in a mitochondrial disorder //J. Neurol. Neurosurg. Psychiatry. – 1991. – 54, №12. – P.1073-1076.
  18. Ueda Y., Doi T., Tokumaru J. et al. Kindling phenomena induced by repeated short-term high potassium stimuli in the ventral hippocampus of rats: on-line monitoring of extracell glutamate overflow // Exp. Brain Res. – 2000. – 135, N 2.– P.199-203.
  19. 19. Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases //Science. -1992. - 256. - P.628-632.

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