Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 64-71

CARDIOVASCULAR PROTECTIVE PROCESSES INDUCED BY METOPROLOL IN RATS WITH EXPERIMENTAL IRRITABLE BOWEL SYNDROME

V.I. Tarasova, M.V. Yermolayeva, K.V. Liventsova

    Donetsk National Medical University, Liman, Ukraine
DOI: https://doi.org/10.15407/fz65.05.064


Abstract

In an experimental model of irritable bowel syndrome in 25 rats the relationship mechanisms between the functional bowel disease and the occurrence of the cardiovascular pathology were evaluated. Metoprolol tartrate was injected intraperitoneally to rats of the test group, control rats received equivalent doses of 0.9% solution of sodium chloride. It was shown that as the functional bowel disorders developed the mean systolic blood pressure increased by 5.7 ± 1.15 mm Hg (4.7%). The revealed histomorphological changes of the heart and blood vessels corresponded to commonly used markers for hypertension. Thus, irritable bowel syndrome is associated with hypertension and cardiac and vascular remodelling. The pronounced antihypertensive influence of metoprolol has a positive cardioprotective effect, reducing the heart weight index by 12.4%, and peryvascular muocardialfybrosis by 38.5%.

Keywords: functional bowel disease; hypertension; metoprolol; blood pressure; heart weight index; remodelling.

Full text: (PDF, in Ukrainian)

References

  1. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell. 2017 Jun 29;170(1):185-98. CrossRef PubMed PubMedCentral
    2.  
  2. Drossman D. Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology. 2016;150(6):1262-79. CrossRef PubMed
    3.  
  3. Salvioli B, Pellegatta G, Malacarne M, Pace F, Malesci A, Pagani M, Lucini D. Autonomic nervous system dysregulation in irritable bowel syndrome. Neurogastroenterol Motil. 2015 Mar;27(3):423-30. CrossRef PubMed
    4.  
  4. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014 May;146(6):1500-12. CrossRef PubMed PubMedCentral
    5.  
  5. Jain P, Hassan AM, Koyani CN, et al. Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress. Front Behav Neurosci. 2015 Jul 10; 9:177. CrossRef PubMed PubMedCentral
    6.  
  6. Elsenbruch S, Holtmann G, Oezcan D, Lysson A, Janssen O, Goebel M et al. Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome? Am J Gastroenterology. 2004 Apr; 99(4): 703-10. CrossRef PubMed
    7.  
  7. Biletsky SV, Boyko VV, Petrynych OA, Kazantseva T.V. Endothelial dysfunction and arterial hypertension [literature review]. Clin Exp Pathol. 2017;1(59):16-163. CrossRef  
  8. Ripley TL, Saseen JJ. β-Blockers: a review of their pharmacological and physiological diversity in hypertension. Ann Pharmacother. 2014 Jun;48(6):723-33. CrossRef PubMed
    9.  
  9. Chan V, Fenning A, Hoey A, Brown L. Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat. J Cardiovasc Pharmacol. 2011;58(4): 424-31. CrossRef PubMed
    10.  
  10. Lewis S, Heaton K. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997; 32(9): 920-4. CrossRef PubMed
    11.  
  11. Opie LH, Commerford PJ, Gersh BJ, Pfeffer MA. Controversies in ventricular remodelling. Lancet. 2006 Jan 28;367(9507):356-67. CrossRef  
  12. Han Y, Huang K, Yao Q, Jiang Z. Mechanobiology in vascular remodeling. Nat Sci Rev. 2018;1097:69-82. CrossRef  
  13. Wang X, Ren R, Liu B, Sentex E, Tappia PS, Dhalla SN. Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat. J Appl Physiol. 2003;94(2):752-63. CrossRef PubMed
    14.  
  14. Olmsted F, Corcoran, AC, and Page IH: Blood pressure in the unanesthetized rat. Circulation.1951;3:727-30. CrossRef PubMed
    15.  
  15. Kohn DF, Barthold SW. Biology and diseases of rats. In: Fox JG, Cohen BJ, Loew FM. Laboratory animal medicine. Orlando, FL: Academic Press, Inc.; 1984. 50 p. CrossRef  
  16. Kristek F, Drobna M, Cacanyiova S. Different structural alterations in individual conduit arteries of SHRs compared to Wistar rats from the prehypertensive period to late adulthood. Physiol. Res. 2017;66:769-80.
    17.  
  17. Soloviev AI, Tishkin SM, Khromov AS, and Stefanov OV. Change in contractive vascular function arterial hypertension of different genesis and its correction with phosphsatidylcholine liposomes. Fiziol. Zh. 2002;48 (6):11-8.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.