CARDIOVASCULAR PROTECTIVE PROCESSES INDUCED BY METOPROLOL IN RATS WITH EXPERIMENTAL IRRITABLE BOWEL SYNDROME
V.I. Tarasova, M.V. Yermolayeva, K.V. Liventsova
Donetsk National Medical University, Liman, Ukraine
DOI: https://doi.org/10.15407/fz65.05.064
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Abstract
In an experimental model of irritable bowel syndrome in 25 rats
the relationship mechanisms between the functional bowel disease
and the occurrence of the cardiovascular pathology were
evaluated. Metoprolol tartrate was injected intraperitoneally
to rats of the test group, control rats received equivalent doses
of 0.9% solution of sodium chloride. It was shown that as the
functional bowel disorders developed the mean systolic blood
pressure increased by 5.7 ± 1.15 mm Hg (4.7%). The revealed
histomorphological changes of the heart and blood vessels
corresponded to commonly used markers for hypertension.
Thus, irritable bowel syndrome is associated with hypertension
and cardiac and vascular remodelling. The pronounced
antihypertensive influence of metoprolol has a positive cardioprotective
effect, reducing the heart weight index by 12.4%,
and peryvascular muocardialfybrosis by 38.5%.
Keywords:
functional bowel disease; hypertension; metoprolol; blood pressure; heart weight index; remodelling.
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