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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 64-71


CARDIOVASCULAR PROTECTIVE PROCESSES INDUCED BY METOPROLOL IN RATS WITH EXPERIMENTAL IRRITABLE BOWEL SYNDROME

V.I. Tarasova, M.V. Yermolayeva, K.V. Liventsova

    Donetsk National Medical University, Liman, Ukraine
DOI: https://doi.org/10.15407/fz65.05.064

Abstract

In an experimental model of irritable bowel syndrome in 25 rats the relationship mechanisms between the functional bowel disease and the occurrence of the cardiovascular pathology were evaluated. Metoprolol tartrate was injected intraperitoneally to rats of the test group, control rats received equivalent doses of 0.9% solution of sodium chloride. It was shown that as the functional bowel disorders developed the mean systolic blood pressure increased by 5.7 ± 1.15 mm Hg (4.7%). The revealed histomorphological changes of the heart and blood vessels corresponded to commonly used markers for hypertension. Thus, irritable bowel syndrome is associated with hypertension and cardiac and vascular remodelling. The pronounced antihypertensive influence of metoprolol has a positive cardioprotective effect, reducing the heart weight index by 12.4%, and peryvascular muocardialfybrosis by 38.5%.

Keywords: functional bowel disease; hypertension; metoprolol; blood pressure; heart weight index; remodelling.

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