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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 56-63

АNTIOXIDANT DEFENSE SYSTEM STATE IN THE LIVER AND THE MYOCARDIUM OF RATS UNDER CONDITIONS OF ACUTE HYPOXIA-HYPERCAPNIA

S.V. Khyzhnyak1, V.S. Morozovа1, S.V. Midyk1, T.V. Poltavchenko2, A.A. Kaplia1

  1. National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine
  2. National University of Water Management and Environmental Management, Rivne, Ukraine
DOI: https://doi.org/10.15407/fz65.05.056


Abstract

The prooxidant-antioxidant state of rat tissues in the formation of adaptive processes in acute hypoxia-hypercapnia with lower body temperature was evaluated. The decrease of the content of 2-thiobarbituric acid reactive substances (TBARS) in liver and myocardial tissues by 48.2 and 51.0%, respectively is shown, it indicates the oxidative processes inhibition in the tissues. The liver superoxide dismutase (SOD) activity decreased by 24.2% mainly due to its Cu, Zn-SOD molecular form and catalase activity increased by 29.4%. In the myocardium the activity of SOD increased by 62.7% mainly due to Mn-SOD molecular form and catalase activity decreased by 21.9%. Тhe studied parameters return to the control values 24 h after withdrawal of the effect of the hypoxia-hypercapnia. It was shown that differently directed changes of the glutathione peroxidase activity and reduced glutathione content in tissues play a compensatory role in hypoxia-hypercapnia.It is concluded that during acute hypoxia-hypercapnia the course of oxidative processes in the rat’s body is controlled by the antioxidant defense system. The possible regulatory role of hypercapnia in these conditions is discussed.

Keywords: hypercapnia; hypoxia; liver; myocardium; superoxide dismutase; catalase; glutathione.

Full text: (PDF, in Ukrainian)

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