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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 56-63


S.V. Khyzhnyak1, V.S. Morozovа1, S.V. Midyk1, T.V. Poltavchenko2, A.A. Kaplia1

  1. National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine
  2. National University of Water Management and Environmental Management, Rivne, Ukraine


The prooxidant-antioxidant state of rat tissues in the formation of adaptive processes in acute hypoxia-hypercapnia with lower body temperature was evaluated. The decrease of the content of 2-thiobarbituric acid reactive substances (TBARS) in liver and myocardial tissues by 48.2 and 51.0%, respectively is shown, it indicates the oxidative processes inhibition in the tissues. The liver superoxide dismutase (SOD) activity decreased by 24.2% mainly due to its Cu, Zn-SOD molecular form and catalase activity increased by 29.4%. In the myocardium the activity of SOD increased by 62.7% mainly due to Mn-SOD molecular form and catalase activity decreased by 21.9%. Тhe studied parameters return to the control values 24 h after withdrawal of the effect of the hypoxia-hypercapnia. It was shown that differently directed changes of the glutathione peroxidase activity and reduced glutathione content in tissues play a compensatory role in hypoxia-hypercapnia.It is concluded that during acute hypoxia-hypercapnia the course of oxidative processes in the rat’s body is controlled by the antioxidant defense system. The possible regulatory role of hypercapnia in these conditions is discussed.

Keywords: hypercapnia; hypoxia; liver; myocardium; superoxide dismutase; catalase; glutathione.


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