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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 49-55

The influence of melatonin on carbohydrate metabolism in muscles of alloxan diabetic rats

I.M. Yaremii1, O.Yu. Kushnir1, V.I. Shvets1, I.R. Yanchii2, N.V. Shvets1

  1. Higher Education Institution in Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine
  2. V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz65.05.049


Abstract

The aim of this study was to determine the influence of melatonin on basal level of glucose in the blood (BG), glycogen content (GC), activities of glucose-6-phosphate dehydrogenase (G6PD), pyruvate kinase (PK) and lactate dehydrogenase (LDH) in muscles of alloxan diabetic rats under conditions of different photoperiod (artificial equinox, constant darkness and constant light). In the DM rats the LDH activity increased on average by 61%, whereas the GC and the activities of PK and G6PD decreased on average by 37, 53 and 40% respectively compared with control values. All of these changes were not dependent on the light conditions. The BG level of the IGT rats didn’t reliably differ from the control, however, the LDH and the G6PD activities were respectively higher on average by 24 and 49%, except rats under the constant light conditions whose G6PD activity was lower by 48%. A melatonin administration (14 daily injections of 10 mg/kg) led to an improvement of the carbohydrate metabolism: the BG level, the GC, the activities of PK and LDH were normalized, while the G6PG activity was increased by an average of 32%. The influence of melatonin was more prominent in the IGT rats under the constant light conditions.

Keywords: melatonin; alloxan diabetes; carbohydrate metabolism; muscles; rats.

Full text: (PDF, in English)

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