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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 25-29


Influence of adrenoceptor agonists and changesin intracellular cyclic nucleotides concentration on the membrane potential of isolatedendothelial cell layer from rabbit aorta

V.V.Yarotsky V.F. Sagach S.M.Marchenko

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev


Abstract

The influence of adrenoceptor agonists and changes in the intracellular cyclic nucleotide concentration on the membrane potential of an isolated endothelial cell layer from rabbit aorta has been investigated. The β1-adrenoceptor agonist phenylephrine evoked deep depolarization of the endothelium of an intact aorta, but had a little effect on the membrane potential of the isolated endothelium. The nonselective adrenoceptor agonist noradrenaline, the β-adrenoceptor agonist isoproterenol and the inhibitor of phosphodiesterases IBMX all strongly depolarized the isolated endothelium. These data suggest that the rise in cyclic nucleotide concentration depolarizes endothelial cells, and this fact may account for the noradrenaline-induced depolarization of the endothelium through β-adrenoceptors.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.