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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(5): 20-27

Changes in biochemical parameters and mitochondrial factor in blood of amateur athletes under influence of marathon running

Y.D. Vinnіchuk1, A.O. Polischchuk1, Y.V. Goshovska2, O.S. Sokolova1, V.F. Sagach2, S.B. Drozdovska1

  1. National University of Ukraine on Physical Education and Sport, Kyiv, Ukraine
  2. Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine


Detailed laboratory tests help to evaluate the body condition of athletes who accomplish marathon distance, choose right means of recovery, and thus prevent the development of pathology. The biochemical parameters of blood were described at rest, after finish and after 24 h of recovery. The opening of mitochondrial permeability transition pores as a possible marker of muscle fatigue was tested as mitochondrial factor release (increased OD of blood serum in UV diapason). Our results showed that biochemical markers that need to be controlled in amateur marathon runners include metabolism regulation indicators – aspartate aminotransferase activity (GOT), total creatine kinase (CK NAK), and their ratio (CK NAK/GOT). The GOT level significantly increased by 1.8 times after the marathon and by 2.4 times after 24 h of recovery. The level of CK NAK and CK NAK/GOT ratio after 24 h of recovery increased by 11.7 and 4.8 times, respectively. The increased activity of sarcoplasmic GOT and CK NAK enzymes, the CK NAK/GOT ratio can indicate the likelihood of skeletal muscle damage. The mitochondrial factor was not detected in the blood neither in resting-state nor after marathon running. These data support the conclusion made after analysis of the biochemical indexes about the satisfactory energy balance of amateur athletes tested.

Keywords: marathon; amateur runners; biochemical homeostasis; mitochondrial permeability transition pore.


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