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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(4): 12-19


INCIDENCE OF ALLELIC POLYMORPHISMS I337V, E23K OF KCNJ11 GENE AND S1369A OF ABCC8 GENE ENCODING KATP-CHANNELS, IN PATIENTS WITH MYOCARDIAL INFARCTION, ARTERIAL HYPERTENSION AND HEART FAILURE

R.B. Strutynskyi1, O.M. Parkhomenko2, L.G. Voronkov2, M.V. Khaitovych3, L.I. Misiura4, I.D. Mazur2, V.E. Dosenko1

  1. O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
  2. State Institution «National scientific center «M.D.Strazhesko Institute of Cardiology» National Аcademy of Medical Sciences of Ukraine, Kyiv, Ukraine
  3. O.O. Bogomoletz National Medical University, Kyiv, Ukraine
  4. Children’s Clinical Hospital №6, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.04.012

Abstract

ATP-sensitive potassium channels (KATP-channels) have an exclusive cardioprotective role in endogenous heart protection from ischemic damage and regulate vascular tone. KCNJ11 (Kir6.2) polymorphisms I337V (rs5215) and G23L (rs5219, E23K), and ABCC8 (SUR1) polymorphisms S1369A (rs757110) was genotyped in 529 patients with myocardial infarction, acute and chronic heart failure, in adolescents with primary hypertension, and as control group in clinically healthy subjects of Ukraine population by the real-time polymerase chain reaction (RT-PCR). It was shown that the frequency of genotypes Glu/Glu, Glu/Lys and Lys/Lys of polymorphism E23K, and genotypes Ser/Ser, Ser/Ala and Ala/Ala of polymorphism S1369A was as follows: in 107 patients with myocardial infarction - 40.2, 43.9 and 15.9%; in 96 patients with acute heart failure - 41.7, 42.7 and 15.6%; in 99 patients with chronic heart failure - 43.4, 44.4 and 12.1%; in 104 adolescents with primary hypertension - 41.4, 46.2 and 12.5% respectively. The distribution of these genotypes in the control group in 98 clinically healthy people was 37.8, 46.9 and 15.3% respectively. Inheritance of SNPs E23K and S1369A were linked. The frequency of genotypes Ile/Ile, Ile/Val and Val/Val of polymorphism I337V was as follows: in 102 patients with myocardial infarction - 32.4, 51.0 and 16.7%; in 93 patients with acute heart failure - 37,6, 43,0 and 19,4%; in 98 patients with chronic heart failure - 40,8, 44,9 and 14,3%; in 90 clinically healthy people - 35.6, 45.6 and 18.9% respectively. Incidence of allelic polymorphisms I337V, E23K and S1369A corresponds to Hardy-Weinberg principle. By criterion χ2, no significant differences were found between the groups. Thus, the frequency of allele polymorphisms I337V, E23K, and S1369A in patients with myocardial infarction, acute and chronic heart failure, and primary hypertension in adolescents was determined, and it has been shown that it does not significantly differ from the frequency in clinically healthy residents of Ukraine.

Keywords: allelic polymorphisms; KCNJ11; ABCC8; I337V; E23K; S1369A; KATP channels; myocardial infarction; heart failure; arterial hypertension

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