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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 61-72


Nonel approaches to correction of mitochondrial dysfunction and oxidative disorders in Parkinson’s disease

O. Gonchar1, I. Mankovska1, K. Rozova1, L. Bratus1, I. Karaban2

  1. O.O.Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. D.F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.061

Abstract

Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). The uses of mitochondria-targeted protective compounds that prevent or minimize a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD. This review discusses the latest findings in this field obtained in PD patients and animal and cellular models of PD with focusing on the effects of pharmacological agents on mitochondrial biogenesis, fission, fusion, mitophagy machinery, and transcription of endogenous cytoprotective antioxidant enzymes. We have also presented the data concerning the technologies for research and screening novel bioactive molecules to target mitochondrial dysfunction in Parkinson’s disease.

Keywords: Parkinson’s disease, mitochondrial dysfunction, mitochondria-targeted protective compounds.

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