DIABETES MELLITUS AND PULMONARY CIRCULATION (PART 2)
N.V. Dobrelia, A.S. Khromov
SI “Institute of Pharmacology and Toxicology National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.047
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Abstract
Increase in blood glucose is accompanied by NO-dependent
dilatation in the vessels of both systemic and pulmonary
circulation and an increase the blood concentration of
endothelin. The increase in blood endothelin levels in patients
with diabetes mellitus (DM) correlates with hyperglycemia
and HbA1c level as well as with the oxidative stress. In the
systemic circulation, there is a significant increase in the
expression of endothelin mRNA receptors of all types, but in
the lungs, the overexpression of type A receptor predominates
and only a slight increase in expression of type B receptor
occurs. The content of arachidonic acid and its metabolites
with resulting responses of the vessels are significantly
altered in the circulatory in diabetes mellitus. The formation
and excretion of constrictor compounds is enhanced, and
the number of vasorelaxants is reduced. Data on changes
in the concentration and effect on the reaction of vessels of
hydroperoxyecososetraenoic acids and lipoxin A4 are absent
under the conditions of the DM. The diabetes influence on the
ion channels in the pulmonary arteries needs to be studied. It
has been demonstrated that diabetes does not affect KV protein
expression in these vessels but suppresses the corresponding
current. It has been shown that TRPM channel expression in
the lung vessels is decreased in diabetes, but their activation
due to ROS is significantly increased. Hyperglycemia, insulin
resistance, endothelial dysfunction in diabetes mellitus may
be responsible for changes in the pulmonary circulation and
may provoke pulmonary vascular disturbances.
Keywords:
diabetes mellitus; hyperglycemia; pulmonary artery; endothelial dysfunction; ion canal.
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