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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 41-46


CHANGES OF THE ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN MEN WITH ARTERIAL HYPERTENSION, OBESITY AND GOUT

I.P. Vakalyuk, M.O. Vatseba

    SHEI «Ivano-Frankivsk National Medical University», Ukraine
DOI: https://doi.org/10.15407/fz65.03.041

Abstract

Investigated endothelial function and arterial rigidity of vessels in patients with essential hypertension (EH) with obesity and gout, the main group, and without obesity and gout, is a group of comparison. It was established that in patients of both groups decreased endothelium dependent vasodilation (EDV) and endothelial-independent vasodilation (EIV), respectively. Thus, EDV was lower by 58.02 and 39.09% in patients with primary and comparative groups and EIV by 36.17 and 30.59%, respectively. Also, the rate of pulse wave propagation was higher compared to healthy people. In patients with obesity and gout, this figure was 2.55 m/s more than the same in patients without concomitant pathology. The value of the Cardio-ankle vascular index with and without comorbidity was 59.72 and 35.89% higher than that of healthy subjects. A significant increase in the thickness of the intima-media complex was found in patients of both groups. Thus, obesity and gout worsen the course of EH by affecting the stiffness of the arterial wall and contributing to endothelial dysfunction.

Keywords: endothelial function; arterial stiffness; the vessels

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