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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 28-33


CHARACTERISTICS OF WATER-SALT BALANCE IN PROTEIN-DEFICIENCY RATS WITH ACETAMINOPHEN-INDUCED TOXIC INJURY

O.M. Voloshchuk, G.P. Kopylchuk

    Yuriy Fedkovych Chernivtsi National University, Ukraine
DOI: https://doi.org/10.15407/fz65.03.028

Abstract

Indicators of the water-salt balance in rats under the conditions of acetaminophen-induced injury and alimentary protein deficiency were studied in the research. Blood levels of Na+, K+, Mg2+, Cl- ions were measured by method of spectrophometry using reagent sets (Human, Germany). Aldosterone level was determined by enzyme-linked immunosorbent assay method using Aldosterone ELISA kit. It is established that significant disturbances of water-salt balance were observed in a group of animals with the toxic acetaminophen-induced injury against the background of alimentary protein deficiency. In animals of the combined pathology group a hypernatremia (Na+ content increased by 25%), hyperchloremia (Cl- content increased by 30%) along with hypokalemia (K+ content decreased by 20%) and hypomagnesemia (Mg2+ content decreased by 1,8 times) was revealed, indicating the formation of ion imbalance. A simultaneous increase in aldosterone level in 2,2 times and plasma hyperosmoralily indicates the formation of the state of hyperhydration. The obtained results can be used to develop a strategy for correction of water-salt balance disturbances in conditions of acetaminophen-induced toxic injury on the background of alimentary protein deficiency.

Keywords: alimentary protein deprivation; acetaminophen; toxic damage; electrolytes; osmolarity; aldosterone.

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