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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 22-27


THE EFFECT OF METHIONINE ON THE ORGANIC MATRIX OF THE BONE TISSUE OF WISTAR RATS OF DIFFERENT AGES

I.G.Litovka 1, V.Ya.Berezovsky1, S.P.Veselsky2

  1. O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine,
  2. Institute of High Technologies of the Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.022

Abstract

The effect of methionine on bone remodeling parameters of young and adult male rats Vistar was studied. The introduction of excess methionine (250 mg / kg for 21 days) in the diet raises the physiological regeneration of bone tissue in young rats. Increasing their alkaline phosphanase activity in bone tissue testifies to the domination of the osteosynthetic phase of osteogenesis relative to osteolytic. Such a reaction is typical for increasing the number of active osteoblasts or increasing the sensitivity of their receptors. Unlike young animals, in adult male rats, age-related bone tissue changes are manifested in the domination of the osteolytic phase. The obtained results testify to the disease-dependent differences in the effect of the same factor dose on the processes of physiological regeneration and the organic matrix of bone tissue rats in males, which should be taken into account when using medicinal preparations.

Keywords: methionine; physiological regeneration of bone tissue

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