EFFECT OF PROPARGYLGLYCINE ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION DURING HEMIPARKINSONISM
K.O. Drachuk, B.S. Kopjak, V.F. Sagach
Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.003
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Abstract
We studied the effect of propargylglycine, a blocker of the
cystathionine-ɣ-lyase-dependent pathway of hydrogen sulfide
synthesis, on endothelium-dependent vascular relaxation in
rats with hemi-parkinsonism. It was found a violation of
endothelium-dependent relaxation in this group of animals.
The average value of its amplitude was 20.6 ± 5.4,% compared
with 64.9 ± 3.5,% in healthy adult rats. The addition
of propargylglycine to the perfusion solution significantly
improved endothelium-dependent relaxation in animals with
hemi-parkinsonism. Thus, the average value of its amplitude
increased from 20.6 ± 5.4,% to 146.8 ± 24.2,%. The basis
of this effect could be the previously established ability of
propargylglycine to inhibit oxidative stress, restore the coupling
cNOS, and increase constitutive synthesis of NO, main
endogenous vasorelaxation factor.
Keywords:
Parkinsonism; endothelial dysfunction; hydrogen sulfide; nitric oxide
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