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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 3-6


K.O. Drachuk, B.S. Kopjak, V.F. Sagach

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


We studied the effect of propargylglycine, a blocker of the cystathionine-ɣ-lyase-dependent pathway of hydrogen sulfide synthesis, on endothelium-dependent vascular relaxation in rats with hemi-parkinsonism. It was found a violation of endothelium-dependent relaxation in this group of animals. The average value of its amplitude was 20.6 ± 5.4,% compared with 64.9 ± 3.5,% in healthy adult rats. The addition of propargylglycine to the perfusion solution significantly improved endothelium-dependent relaxation in animals with hemi-parkinsonism. Thus, the average value of its amplitude increased from 20.6 ± 5.4,% to 146.8 ± 24.2,%. The basis of this effect could be the previously established ability of propargylglycine to inhibit oxidative stress, restore the coupling cNOS, and increase constitutive synthesis of NO, main endogenous vasorelaxation factor.

Keywords: Parkinsonism; endothelial dysfunction; hydrogen sulfide; nitric oxide


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