Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 3-6


EFFECT OF PROPARGYLGLYCINE ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION DURING HEMIPARKINSONISM

K.O. Drachuk, B.S. Kopjak, V.F. Sagach

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.003

Abstract

We studied the effect of propargylglycine, a blocker of the cystathionine-ɣ-lyase-dependent pathway of hydrogen sulfide synthesis, on endothelium-dependent vascular relaxation in rats with hemi-parkinsonism. It was found a violation of endothelium-dependent relaxation in this group of animals. The average value of its amplitude was 20.6 ± 5.4,% compared with 64.9 ± 3.5,% in healthy adult rats. The addition of propargylglycine to the perfusion solution significantly improved endothelium-dependent relaxation in animals with hemi-parkinsonism. Thus, the average value of its amplitude increased from 20.6 ± 5.4,% to 146.8 ± 24.2,%. The basis of this effect could be the previously established ability of propargylglycine to inhibit oxidative stress, restore the coupling cNOS, and increase constitutive synthesis of NO, main endogenous vasorelaxation factor.

Keywords: Parkinsonism; endothelial dysfunction; hydrogen sulfide; nitric oxide

References

  1. Talanov SO, Tkachenko MM, Baziliuk OV, Stepanenko LH, Sahach VF. Influence of enalapryl on vasomotor reactions of rats with chronic deficiency of dopamine in the mesencephalo-striatal system. Fiziol Zh. 2007;53(3):16- 22 [Ukrainian].
  2.  
  3. Talanov SA, Tkachenko MN, Bazilyuk OV, Stepanenko LG, Sagach VF. Shemo- and mechano-induced reactions of vascular smooth muscles in rats with chronic insufficiency of cerebral dopamine: effect of co-enzyme Q10. Neurophysiology. 2009;41(3):206-211 [Ukrainian]. CrossRef  
  4. Streeter E, Ng HH, Hart JL. Hydrogen sulfide as a vasculoprotective factor. Med Gas Res. 2013;3(1):1-9. CrossRef PubMed PubMedCentral
  5.  
  6. Kondo K, Bhushan S, King AL, Prabhu SD, Hamid T, Koenig S, et al. H2S protects against pressure overloadinduced heart failure via upregulation of endothelial nitric oxide synthase. Circulation. 2013;127(10):1116-27. CrossRef PubMed PubMedCentral
  7.  
  8. Gil V, Gallego D, Jiménez M. Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility. Br J Pharmacol. 164(2b):485-98. CrossRef PubMed PubMedCentral
  9.  
  10. Drachuk KO, Kotsjuruba AV, Bazilyuk OV, Stepanenko LG, Sagach VF. Propargylglycine restores endothelium- dependent relaxation of aortic smooth muscle in old rats. Fiziol Zh. 2014;60(4):3-10 [Ukrainian]. CrossRef  
  11. Drachuk KO, Dorofeyeva NA, Kotsuruba AV, Sagach VF. Propargylglycine as a possible factor of the diastolic function restoration in old rats. Int J Phys Pathophysiol. 2016;7(3):1-8. CrossRef  
  12. Ungerstedt U. Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiol. 1970;82:69-93. CrossRef  
  13. Talanov SA, Kotsiuruba AV, Korkach IuP, Sahach VF. Oxidative stress in the cardiovascular system of rats with chronic deficiency of cerebral dopamine. Fiziol Zh. 2009;55(4):32-40 [Ukrainian].
  14.  
  15. El Assar M, Angulo J, Vallejo S, Peiró C, Sánchez-Ferrer CF, Rodríguez-Mañas L. Mechanisms involved in the aging-induced vascular dysfunction. Front Physiol. 2012;28;3:132. CrossRef PubMed PubMedCentral
  16.  
  17. Vásquez-Vivar J, Kalyanaraman B, Martásek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic Res. 2003;37(2):121-7. CrossRef PubMed
  18.  
  19. Galougahi KK, Liu CC, Gentile C, Kok C, Nunez A, Garcia A, et al. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction. J Am Heart Assoc. 2014;3(2):e000731. CrossRef PubMed PubMedCentral
  20.  
  21. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res. 2005;66(2):286-94. CrossRef PubMed
  22.  
  23. Fu Q, Song R, Yang Z, Shan Q, Chen W. 6-Hydroxydopamine induces brain vascular endothelial inflammation. IUBMB Life. 2017; 69(11):887-895. CrossRef PubMed
  24.  
  25. de Jager L, Amorim EDT, Lucchetti BFC, Lopes FNC, Crestani CC, Pinge-Filho P, Martins-Pinge MC. Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise. Life Sci. 2018;204:78-86. CrossRef PubMed
  26.  
  27. Drachuk KO, Kotsjuruba A, Sagach V. Modulators of hydrogen sulfide restore endothelium-dependent relaxation of aortic smooth muscles in old rats. Eur J Heart Fail. 2016;17:31.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.