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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(2): 89-96


LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE STATUS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND CONCOMITANT HYPOTHYROIDISM

S.V. Feysa

    Uzhhorod National University, Ukraine
DOI: https://doi.org/10.15407/fz65.02.089

Abstract

The goal of the study was to investigate the intensity of lipid peroxidation (LPO) and activity of the antioxidant defense system (ADS) of patients with non-alcoholic fatty liver disease (NAFLD) on the background of carbohydrate methabolism disorders (type 2 diabetes mellitus or pre-diabetes), including with concomitant hypothyroidism, to justify the advisability of prescribing antioxidants. 117 patients and 20 healthy persons (control group) were examined. The intensity of LPO was estimated by the plasma level of malonic dialdehyde, the ADSstatus – by the activity of erythrocytes catalase and superoxide dismutase. The significant increase of lipid peroxidation activity with minor changes in ADS were detected in patients with NAFLD: the levels of catalase and superoxide dismutase, despite a tendency to decrease, did not differ significantly from the corresponding indices of a healthy persons group. In cases when NAFLD combines with other concomitant diseases LPO activity is more intensive than in patients with NAFLD without concomitant diseases. In patients with metabolic syndrome and non-alcoholic steatohepatitis (NASH) increasing activity of NASH leads to the intensity of LPO increases. In patients with NASH the intensity of ADS is higher in cases of mild hepatitis activity, in cases when the hepatitis activity is increasing, the intensity of ADS is decreasing. That fact indicates about the depletion of antioxidant reserves of the body in cases when the liver inflammatory changes are growing.

Keywords: Key words: lipid peroxidation; antioxidant system; nonalcoholic fatty liver disease; diabetes mellitus; pre-diabetes; subclinical hypothyroidism

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