Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(2): 89-96

LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE STATUS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND CONCOMITANT HYPOTHYROIDISM

S.V. Feysa

    Uzhhorod National University, Ukraine
DOI: https://doi.org/10.15407/fz65.02.089


Abstract

The goal of the study was to investigate the intensity of lipid peroxidation (LPO) and activity of the antioxidant defense system (ADS) of patients with non-alcoholic fatty liver disease (NAFLD) on the background of carbohydrate methabolism disorders (type 2 diabetes mellitus or pre-diabetes), including with concomitant hypothyroidism, to justify the advisability of prescribing antioxidants. 117 patients and 20 healthy persons (control group) were examined. The intensity of LPO was estimated by the plasma level of malonic dialdehyde, the ADSstatus – by the activity of erythrocytes catalase and superoxide dismutase. The significant increase of lipid peroxidation activity with minor changes in ADS were detected in patients with NAFLD: the levels of catalase and superoxide dismutase, despite a tendency to decrease, did not differ significantly from the corresponding indices of a healthy persons group. In cases when NAFLD combines with other concomitant diseases LPO activity is more intensive than in patients with NAFLD without concomitant diseases. In patients with metabolic syndrome and non-alcoholic steatohepatitis (NASH) increasing activity of NASH leads to the intensity of LPO increases. In patients with NASH the intensity of ADS is higher in cases of mild hepatitis activity, in cases when the hepatitis activity is increasing, the intensity of ADS is decreasing. That fact indicates about the depletion of antioxidant reserves of the body in cases when the liver inflammatory changes are growing.

Keywords: Key words: lipid peroxidation; antioxidant system; nonalcoholic fatty liver disease; diabetes mellitus; pre-diabetes; subclinical hypothyroidism

Full text: (PDF, in Ukrainian)

References

  1. Kontorshchikova KN. Peroxide oxidation of lipids in norm and pathology: tutorial. N. Novgorod: NizhGMA; 2000. [Russian].
    2.  
  2. Ovsyannikova LM, Nosach EV. Antioxidant medicines: the problem of choice. Doctor. 2003;1:74-6. [Russian].
    3.  
  3. Day CP. From fat to inflammation. Gastroenterology.2006; 130:207-10. CrossRef PubMed
    4.  
  4. Govoruxa OYu, Shnajderman OYu. The value of the interaction of lipid peroxidation and antioxidant systems in the development of pathological processes. Theor and Exp Med. 2016;4(73):10-4 [Ukrainian].
    5.   Harchenko NV. Free radical oxidation and antioxidant defense status in patients with chronic hepatitis. Gastroenterology. 2001;32:504-9. [Ukrainian]  
  5. Aboutwerat A. Pemberton P, Smith A, Burrows PC, McMahon RF. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta, Mol Bas Dis. 2003;1637(2):142-50. doi: 10.1016/s0925- 4439(02)00225-9. CrossRef  
  6. Albano E. Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radic Biol Med. 2002;32(2):110-14. doi: 10.1016/s0891- 5849(01)00773-0. CrossRef  
  7. Skvortcov VV. Peroxidation of lipids and antioxidant system in hepatology. Hepatology. 2003;3:7-13. [Russian].
    8.  
  8. Pessayre D, Pessayre B. NASH: a mitochondrial disease. J Hepatol. 2005;42(6):928-40. CrossRef PubMed
    9.  
  9. Petta S, Muratore C, Craxi Petta A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 2009;41(9):615-25. doi: 10.1016/j. dld.2009.01.004. CrossRef PubMed
    10.  
  10. Dowman JK, Tomlinson JW, Newsome PN. Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2011;33(5):525-40. CrossRef PubMed PubMedCentral
    11.  
  11. Vladimirov YuA, Gukasov VM, Fjodorov VK, Sergejev PV. The action of thyroxin on peroxide oxidation of lipids in mitochondrial membranes. Bull Exp Biol and Med. 1977;83(5):558-61. [Russian].
    12.  
  12. Pavlovskyj MP, Timochko MF, Lukavetsky AV, Tkachenko OR. Processes of lipid peroxidation in the blood and liver tissue during hypo- and hyperfunction of the thyroid gland in the experiment. Probl Pathol in the Exp and Clin. 1986;8:114-5. [Russian].
    13.  
  13. Erdamar H, Demirci H, Yaman H et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008;46(7):1004-10. CrossRef PubMed
    14.  
  14. Gredilla R, López-Torres M, Portero-Otín M, Pamplona R, Barja G. Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle. Mol Cell Biochem. 2001;221(1-2):41-8. CrossRef PubMed
    15.  
  15. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM. 2010;103: 71-83. CrossRef PubMed PubMedCentral
    16.  
  16. Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular Material nadiishov do redaktsii 25.10.2018 disease among type 2 diabetic patients. Diabetes Care. 2007;30(9):1212-8. CrossRef PubMed
    17.  
  17. Biochemical and biophysical methods for evaluating the disturbances of oxidative homeostasis in persons who have undergone radiation influence as a result of the Chernobyl accident. Methodical recommendations of the Scientific Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine. Kyiv, 1999:18. [Ukrainian].
    18.  
  18. Koroljuk M, Ivanova L, Majorova I. Lab Med. 1988;1:16-8. [Russian].
    19.  
  19. Dorosh OG. Stage of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus with lipid peroxidation products (literature review and own data). Probl Endocrine Pathol. 2013;4:63-77. [Ukrainian].
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.