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CONTENT OF AFFERENT AND EFFECTORS CELLS, REGULATORY CYTOKINES OF HYPERTROPHY AND CHRONIC INFLAMMATION PALATINE TONSILS IN CHILDREN WERE ESTIMATED
O.Melnykov1 , O.Bredun2 , M.Timchenko1 , S.Bredun2
- State Institution “Institute of Otolaryngology
O.S. Kolomiychenko NAMS of Ukraine ”, Kyiv, Ukraine{/li]
- Shupyk National Medical Academy of Postgraduate
Education, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.02.084
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Abstract
The relative content of dendritic cells (CD80+), macrophages
(CD14), IgA antibody, B-lymphocytes (CD20), natural killer
cells (CD16), and cytokine production: interleukin-4 and
γ-interferon were determined. Cell suspensions were obtained
from palatine tonsils of 22 children when conducting appropriate
surgical interventions on the tonsils with hypertrophy
and chronic tonsillitis. Statistical analysis of nonparametric
criterion was used. The number of dendritic cells in the tonsils
of children with hypertrophy and chronic tonsillitis was
approximately equal, while macrophages were predominant
in chronic tonsillitis. IgA-producing and B-lymphocytes
were greater in the tonsils with hypertrophy, and NK-cells in
chronic tonsillitis. The production of γ-interferon prevailed
in the hypertrophy. Studies show a higher cellular and humoral
immunological potential of tonsils cells in children
with hypertrophy compared with chronic tonsillitis, and this
trend is maintained both at the level of factors of specific and
congenital immunity.
Keywords:
tonsils; hypertrophy; chronic tonsillitis; immunologic potential; cytokines.
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