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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(2): 84-88


CONTENT OF AFFERENT AND EFFECTORS CELLS, REGULATORY CYTOKINES OF HYPERTROPHY AND CHRONIC INFLAMMATION PALATINE TONSILS IN CHILDREN WERE ESTIMATED

O.Melnykov1 , O.Bredun2 , M.Timchenko1 , S.Bredun2

  1. State Institution “Institute of Otolaryngology O.S. Kolomiychenko NAMS of Ukraine ”, Kyiv, Ukraine{/li]
  2. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.02.084

Abstract

The relative content of dendritic cells (CD80+), macrophages (CD14), IgA antibody, B-lymphocytes (CD20), natural killer cells (CD16), and cytokine production: interleukin-4 and γ-interferon were determined. Cell suspensions were obtained from palatine tonsils of 22 children when conducting appropriate surgical interventions on the tonsils with hypertrophy and chronic tonsillitis. Statistical analysis of nonparametric criterion was used. The number of dendritic cells in the tonsils of children with hypertrophy and chronic tonsillitis was approximately equal, while macrophages were predominant in chronic tonsillitis. IgA-producing and B-lymphocytes were greater in the tonsils with hypertrophy, and NK-cells in chronic tonsillitis. The production of γ-interferon prevailed in the hypertrophy. Studies show a higher cellular and humoral immunological potential of tonsils cells in children with hypertrophy compared with chronic tonsillitis, and this trend is maintained both at the level of factors of specific and congenital immunity.

Keywords: tonsils; hypertrophy; chronic tonsillitis; immunologic potential; cytokines.

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