Comparative evaluation of renal, pleiotropic and myotropic effects of statins in rats
V.G. Zeleniuk, I.I. Zamorskii, O.V. Gerush, T.S. Shchudrova, O.M. Goroshko, A.R. Zeleniuk
Higher state educational establishment of Ukraine “Bukovinian state medical university”, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz65.02.076
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Abstract
The effect of certain statins with different lipophilicity (atorvastatin (ATO), lovastatin (LOV), simvastatin
(SIM)) on renal function of apparently healthy rats at a conventionally effective dose of 20 mg/kg was
established. As it has been found in our experiments on the 7th day of statins administration there was
only a slight increase in urine output along with a moderate growth of glomerular filtration rate (GFR)
and decrease in excretion of sodium ions and protein while maintaining the mechanisms of intrarenal
autoregulation. Renotropic action of statins, among various mechanisms, was evoked by their pleiotropic
effects what was confirmed by the presence of correspondent correlations. Antioxidant effect of drugs was
evidenced by decreased malondialdehyde (MDA) content and increased catalase (CAT) activity, as well as
by reducing trend of blood plasma proinflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6)
and tumor necrosis factor alpha (TNF-α)). An absence of statins influence on blood plasma transaminase
levels, blood plasma creatine phosphokinase (CPK) activity and skeletal muscles histostructure was also
demonstrated. The most marked renal effect was demonstrated by SIM – the most lipophilic drug among
the studied ones.
Keywords:
statins; renal function; apparently healthy rats: prooxidant-antioxidant balance; interleukins
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