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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(2): 76-83


Comparative evaluation of renal, pleiotropic and myotropic effects of statins in rats

V.G. Zeleniuk, I.I. Zamorskii, O.V. Gerush, T.S. Shchudrova, O.M. Goroshko, A.R. Zeleniuk

    Higher state educational establishment of Ukraine “Bukovinian state medical university”, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz65.02.076

Abstract

The effect of certain statins with different lipophilicity (atorvastatin (ATO), lovastatin (LOV), simvastatin (SIM)) on renal function of apparently healthy rats at a conventionally effective dose of 20 mg/kg was established. As it has been found in our experiments on the 7th day of statins administration there was only a slight increase in urine output along with a moderate growth of glomerular filtration rate (GFR) and decrease in excretion of sodium ions and protein while maintaining the mechanisms of intrarenal autoregulation. Renotropic action of statins, among various mechanisms, was evoked by their pleiotropic effects what was confirmed by the presence of correspondent correlations. Antioxidant effect of drugs was evidenced by decreased malondialdehyde (MDA) content and increased catalase (CAT) activity, as well as by reducing trend of blood plasma proinflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α)). An absence of statins influence on blood plasma transaminase levels, blood plasma creatine phosphokinase (CPK) activity and skeletal muscles histostructure was also demonstrated. The most marked renal effect was demonstrated by SIM – the most lipophilic drug among the studied ones.

Keywords: statins; renal function; apparently healthy rats: prooxidant-antioxidant balance; interleukins

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