Cholesterol-rich diet induced improvement of hemodynamic system indices in SHR
G.V. Portnichenko, S.V. Goncharov, D.O. Stroy, V.E. Dosenko
Bogomoletz Institute of Physiology, NAS of Ukraine, Ukraine
DOI: https://doi.org/10.15407/fz65.02.068
Abstract
Metabolic syndrome is the nowadays problem that arose as a result of changes in lifestyle and diet. Several
of the key factors of this disorder are lipid metabolism disturbances and hypertension. However, there is little
known about combined influence of this factors and their contribution to the functional changes. This work
is aimed to elucidate the effects of cholesterol-rich diet on major hemodynamic indices and lipid metabolism
in SHR rats. The experiments were performed in 6-month old Wistar and SHR rats. Animals were fed for 8
weeks with enriched by cholesterol (3% w/w, Sigma) standard rodent rations. Cardiohemodynamics measured
in vivo by Pressure-sensitive microcatheter 2F (“Millar Instruments”, USA) introduced into left ventricle.
Blood cholesterol profile was measured biochemically. The obtained data, paradoxically, signified that
unlike the Wistar rats in SHR the major heart function parameters like Ejection fraction (31% increase),
Stroke Volume (72% increase), Cardiac Output (69% increase) etc. improved after cholesterol diet. And at
the same time SHR were more resistant to changes in blood lipid composition – they kept the same level of
HDL and reached 46% lower LDL level than Wistar rats. Thus, chronic arterial hypertension reduces the
sensitivity of rats to exogenous cholesterol. Combined influence of cholesterol and hypertension protects
heart function in comparison to normotensive rats.
Keywords:
hypertension; lipid metabolism; cholesterol diet; cardiohemodynamics; spontaneously hypertensive rats.
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