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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(1): 86-96


ROLE OF CALCIUM IONS IN EXCITATION-CONTRACTION COUPLING IN CARDIOMYOCYTES

V.M. Shkryl

    Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine; Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.01.086

Abstract

Calcium is an important signaling element and universal intracellular messenger and the determining ion in the process of Excitation-Contraction Coupling. This review describes calcium receptors at this process in cardiomyocytes. The main sources of increase of intracellular calcium level is entry from extracellular medium by dihydropyridine receptors and release from internal stores, in particular, from the sarcoplasmic reticulum (SR) via activation of ryanodine receptors. The absence of a transverse tubular network in the atria myocytes makes the Ca2+ release process specific to the ventricular cells of the myocardium. Atrial myocytes, but not ventricular, also express inositol triphosphate receptors that complement the regulation of Ca2+ signal. The calcium receptors described in this review reveals in more detail of Excitation-Contraction Coupling and details Ca2+ - dependent regulation of cardiomyocyte.

Keywords: Ca2+, ryanodine receptor, cardiomyocyte, calcium induced calcium release, dihydropyridine receptor

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