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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(1): 50-56


KINETICS OF SINGLE CONTRACTIONS INHIBITION UNDER ISCHEMIA-REPERFUSION AS AN INDICATOR OF M. GASTROCNEMIUS FUNCTIONAL STATE IN RATS

D.M. Nozdrenko, V.M. Soroka, O.M.Khoma

    Taras Shevchenko National University of Kyiv, ESC “Institute of Biology and Medicine”, Ukraine
DOI: https://doi.org/10.15407/fz65.01.050

Abstract

The degradation of strength and lengths of isotonic twitch contractions of rat gastrocnemius muscle under ischemiareperfusion conditions was described in the article. Was demonstrated that strength and lengths recession directly dependent on ischemia and subsequent reperfusion duration. It was found that in the selected conditions detectable muscle contraction reaches zero level after 90-100 minutes of the ischemia. In the reperfusion phase partial contraction restoration was detected. Recovery level depended on preliminary ischemia duration. Maximum recovery level was observed after 4 (2+2) hours of ischemia-reperfusion, strengths restored up to 72±3,2% and lengths reached 7±1,3% of nonischemic control. In the case of 3+3 and 4+4 hours of ischemia-reperfusion function regenerated up to 42±4,1% and 12±2,3% of strengths control accordingly, lengths stayed on zero level in both situations. Contraction properties in reperfusion period recovered to some steady state level that probably allows us to determine muscle damage in ischemia stage. Simples, utility and possibility of noninvasive use of this method of muscle function evaluation can be useful in clinical practice.

Keywords: ischemia-reperfusion; skeletal muscle; isotonic twitch; strength; length.

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