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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(6): 68-76


THE INFLUENCE OF LOW-LEVEL LIGHT RADIATION OF RED SPECTRUM DIAPASON ON GLYCEMIC PROFILE AND PHYSICOCHEMICAL CHARACTERISTICS OF RAT’S ERYTHROCYTES IN DIABETES MELLITUS

O.I. Karmash1, M.Y. Lіuta1, N.V. Yefimenko1, A.M. Korobov2, N.O. Sybirna1

  1. Ivan Franko National University of Lviv, Ukraine
  2. V.N. Karazin Kharkiv National University, Ukraine
DOI: https://doi.org/10.15407/fz64.06.068

Abstract

The influence of low-level light therapy (LLLT) on glycemic indices and physicochemical characteristics of rat’s periphery blood erythrocytes in streptozotocin-induced (60 mg/kg) diabetes mellitus (DM) was investigated. The animals were irradiated by light with wavelength of 630 nm and power of 150 mW with the device analogous to the phototherapeutic apparatus “Barva” (duration of irradiation was 5 min in the course of 10 days). The glucose concentration in whole blood and content of glycosylated hemoglobin in erythrocytes decreased by 37.02 and 15.7 %, respectively, in irradiated DM rats. The irradiation of healthy animals causes the increasing of hemoglobin concentration and reticulocytes content by 26.68 and 41.8 %, respectively, comparing to control. It was revealed that irradiation causes an increase of erythrocyte number and hemoglobin concentration by 20.13 and 20.27 % in DM animals, respectively, and a decrease of reticulocyte number by 45.53 % comparing to the analogues indices in non-irradiated DM rats. The normalized effect of LLLT on erythrocyte hemolysis indices in DM rats were established. LLLT causes a decrease in the level of TBA-positive products in blood plasma and hemolysates of erythrocytes in 1.8 times in healthy animal group. Irradiation of DM rats induces a decrease of TBA-positive products content in plasma and hemolysates of erythrocytes in 1.2 and 1.3 times, respectively, compared to analogues indices in non-irradiated animals.

Keywords: experimental diabetes mellitus, low-level light therapy, peripheral blood erythrocytes

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