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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(6): 40-46


Spatial dimension of nigral astrogliosis observed in rotenone model of Parkinson’s disease

A.O. Bogdaniuk, A.G. Nikonenko

    Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.06.040

Abstract

This paper addresses spatial aspects of reactive astrogliosis observed in the substantia nigra pars compacta (SNc) in rotenone model of Parkinson’s disease. The study was performed on adult male Wistar rats receiving the intracerebral 12 µg rotenone infusion into the left SNc. SNc tissue was analyzed 40, 70 and 200 days after the infusion. It was shown that rotenone caused the increase in astocyte density at all analyzed time-points, thus indicating the proliferation of the cells. Radial distribution function (RDF) analysis demonstrated a non-uniform spatial distribution of nigral astrocytes. Their density was revealed to be higher in the proximity of neuronal cell bodies, especially on the infused side. In addition, RDF analysis provided evidence of spatial clusters of astrocytes 40 days after the infusion. The results of this study suggest that nigral astrogliosis observed in the rotenone model of Parkinson’s disease includes changes in spatial distribution of astrocytes. These changes reflect the rearrangement of SNc tissue architecture occurring in response to rotenone-related degeneration of SNc neurons.

Keywords: animal model; astrocytes; Parkinson’s disease; rotenone; spatial pattern

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