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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(6): 17-22


M.O. Semenikhina, R.I. Bogovyk, M.P. Fedoriuk, O.V. Stasyshyn, A.V. Savotchenko, E.V. Isaeva

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


The present work is devoted to the study of protease-activated receptor 1 (PAR1) contribution to the modulation of social behavior in rats after SE. Using the lithium-pilocarpine model, we demonstrated a significant decline in sociality and social novelty in rats two weeks after SE, what is common comorbid condition for epilepsy. SE group spent less time (5.85 ± 1.11% of total time in the experimental chamber) with «social» stimulus comparing to the control (15.04 ± 1.59%). We also have shown for the first time that PAR1 inhibition does not affect the social behavior of experimental animals both under control and SE conditions, which indicates the absence of the involvement of this receptor in the mechanisms of the social behavior formation in rat.

Keywords: protease-activated receptor 1; social behavior; epileptic status; lithium-pilocarpine model


  1. Tuchman R, Rapin I Review Epilepsy in autism. 2002;1:352-8.
  3. Besag FMC. Epilepsy in patients with autism: links, risks and treatment challenges. Neuropsychiatr Dis Treat. 2018;14:1-10. CrossRef PubMed PubMedCentral
  5. Chao H, Chen H, Samaco RC, et al. GABAergic dysfunction mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2011;468:263-9. CrossRef PubMed PubMedCentral
  7. Bogovik R, Fedoriuk M, Isaev D, Krishtal O, Holmes GL, Isaeva E. Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. Epilepsy Behav. 2017;67:66-9. CrossRef PubMed
  9. Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E. Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. Neurobiol Dis. 2015;78:68-76. CrossRef PubMed PubMedCentral
  11. Breder È, Striggow F, Riek-burchardt M, Kiesel A, Schmidt W, Henrich-noack P, Krug M, Reymann KG, Reiser G. Four different types of protease-activated receptors are widely expressed in the brain and are upregulated in hippocampus by severe ischemia. Eur J Neurosci. 2001;14:595-608. CrossRef PubMed
  13. Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis SF. Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp Neurol. 2004; 188:94-103. CrossRef PubMed
  15. Han K, Mannaioni G, Hamill CE, Lee J, Junge CE, Lee CJ, Traynelis SF. Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus. Mol Brain. 2011; 1-12. CrossRef  
  16. Racine RJ. Modification of seizure activity by electrical modification of after-discharge. Electroencephalogr Clin Neurophysiol. 1972;32:281-94. CrossRef  
  17. Kaidanovich-Beilin O, Lipina T, Vukobradovic I, Roder J, Woodgett JR. Assessment of Social Interaction Behaviors. J Vis Exp. 2011; 1-6. CrossRef  
  18. Crawley JN. Designing mouse behavioral tasks relevant to autistic-like behaviors. Ment Retard Dev Disabil Res Rev. 2004;10:248-58. CrossRef PubMed
  20. Trimble M. Treatment issues for personality disorders in epilepsy. Epilepsia. 2013;54:41-5. CrossRef PubMed
  22. Kim Y, Venkataraju KU, Pradhan K, et al. Mapping social behavior-induced brain activation at cellular resolution in the mouse. Cell Rep. 2015;10:292-305. CrossRef PubMed PubMedCentral
  24. Mula M. Treatment of anxiety disorders in epilepsy: An evidence-based approach. Epilepsia. 2013;54:13-8. CrossRef PubMed
  26. Donovan APA, Basson MA. The neuroanatomy of autism - a developmental perspective. J Anat. 2017;230:4-15. CrossRef PubMed PubMedCentral
  28. Chugani HT, Chugani DC. Imaging of Serotonin Mechanisms in Epilepsy. Epilepsy Curr. 2005;5:201-6. CrossRef PubMed PubMedCentral
  30. Kondziella D, Alvestad S, Vaaler A, Sonnewald U. Which clinical and experimental data link temporal lobe epilepsy with depression? J Neurochem. 2007;103:2136-52. CrossRef PubMed
  32. Almonte AG, Qadri LH, Sultan FA, Watson JA, Mount DJ, Rumbaugh G, Sweatt JD. Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity. J Neurochem. 2013;124(1):109-22. CrossRef PubMed PubMedCentral
  34. Semenikhina M, Bogovyk R, Fedoriuk M, Nikolaienko O, Alkury LT, Savotchenko A, Krishtal O, Isaeva E. Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus. Neurosci Lett 2019;692:64–68. CrossRef PubMed
  36. Bourgognon JM, Schiavon E, Salah-Uddin H, et al. Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala. Mol Psychiatry. 2013;18:1136-45. CrossRef PubMed PubMedCentral
  38. Maggio N, Itsekson Z, Ikenberg B, Strehl A, Vlachos A, Blatt I, Tanne D, Chapman J. The anticoagulant activated protein C (aPC) promotes metaplasticity in the hippocampus through an EPCR-PAR1-S1P1 receptors dependent mechanism. Hippocampus. 2014;24:1030-8. CrossRef PubMed

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