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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(6): 17-22


PROTEASE-ACTIVATED RECEPTOR 1 INHIBITION DOES NOT AFFECT THE SOCIAL BEHAVIOR AFTER STATUS EPILEPTICUS IN RAT

M.O. Semenikhina, R.I. Bogovyk, M.P. Fedoriuk, O.V. Stasyshyn, A.V. Savotchenko, E.V. Isaeva

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.06.017

Abstract

The present work is devoted to the study of protease-activated receptor 1 (PAR1) contribution to the modulation of social behavior in rats after SE. Using the lithium-pilocarpine model, we demonstrated a significant decline in sociality and social novelty in rats two weeks after SE, what is common comorbid condition for epilepsy. SE group spent less time (5.85 ± 1.11% of total time in the experimental chamber) with «social» stimulus comparing to the control (15.04 ± 1.59%). We also have shown for the first time that PAR1 inhibition does not affect the social behavior of experimental animals both under control and SE conditions, which indicates the absence of the involvement of this receptor in the mechanisms of the social behavior formation in rat.

Keywords: protease-activated receptor 1; social behavior; epileptic status; lithium-pilocarpine model

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