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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(6): 3-8

Influence of rs1137101 gene polymorphism of leptin receptor on the development of diabetes mellitus type 2 and obesity

S.V. Ziablitsev1, T.U. Uzvenko2, O.P. Chernobrivtsev1, A.A. Grishov1, S. Palamar1, D.S. Ziablitsev1

  1. Bogomolets National Medical University, Kiev, Ukraine
  2. Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kiev, Ukraine


The aim of this research was a study of gene LEPR polymorphism rs1137101 role in diabetes mellitus 2 type development and his influences on the clinical and laboratory data, related to obesity for these patients. 103 patients are inspected, that had the clinically expressed complications. A control group was made by 100 practically healthy persons of corresponding age. The analysis of polymorphic DNA-loci was carried out by the method of polymerase chain reaction in real time (TaqMan® SNP Genotyping Assay). Results showed that allelic polymorphism of rs1137101 (223Gln>Arg) had been associated with diabetes mellitus 2 types development: allele Gln promotes, while allele Arg – reduces (OR=1.5; P=0.039) the risk of its development. Presence allele Gln for diabetic patients assists development of obesity and his displays, namely – to the higher values of body mass index and HOMA-IR, and also to the greater leptin and triglycerides blood levels on a background reduction of high-density lipoproteides maintenance. The risk of developing obesity in these patients is increased by 1.8 times.

Keywords: diabetes mellitus 2 types; leptin receptor gene; rs1137101


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