We reviewed published articles and own experimental data concerning the hormonal functions of gingival tissues. It is concluded that gingival tissues produce: grelin which is the analogue of the stomach grelin, glucocorticoids cortisone and cortisol. Gingival tissues are functionally connected and interact with the other hormone producing tissues, and with endocrine glands. The interaction is of two types – by humoral and nervous ways. Mechanical irritation of gingival tissues (the movement of a tooth) increases the production of relaxin by ovaries. Mechanism of that is viscero-visceral reflex – gingivoovarial reflex, similar to the eye-cardial Danini Ashner reflex. In the phase of ovulation the antioxidante activity of gingival tissues is the lowest, comparatively to the other phases of the menstrual cycle. Gingivitis and paradontitis decrease the sensitivity of tissues to insulin. Physiological gingival resistance depends on the functional state of retino-hypothalamic-epiphysis system: darkness (stimulation of epiphysis) increases, and bright light decreases the antioxidant activity.