The intensities of oxidative metabolism and nitric oxide production in the trained and untrained female students aged 18-22 years under adaptation to physical load were studied. At the initial stage of the competitive period in the trained students adaptive rearrangements were accompanied by a significant increase in the intensity of the oxidative metabolism (an increase in the rate of generation of the superoxide radical, hydroxyl radical, uric acid content, hydrogen peroxide), production of nitric oxide (increased activity of the constitutive NOS and decrease in the content of the marker of peroxynitrite – nitrate anion) and lipid peroxidation. The growth of the content of TBA-active products indicates the intensification of these processes. High (r≥0.70) correlation dependence among trained girls students between the functional state of the organism and the indicators of the intensity of oxidative metabolism and nitric oxide production was revealed. Our results point for the important role of these processes in the formation of adaptive changes in the body under systematic physical load.