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Correlations between polymorphisms of double-strand break DNA repair genes and risk of bronchopulmonary pathology development in hazardous industries workers
T.A. Andrushchenko1, S.V. Goncharov2, V.E. Dosenko2
- State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical
Sciences of Ukraine», Kyiv, Ukraine
- Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.05.026
Abstract
The study in the group of workers of asbestos-cement plants and miners of allelic variants of XRCC7
(rs7003908) and ATM (rs664677) polymorphisms encoding the double-strand break repair DNA (n=215).
These polymorphisms are recognized markers of cancer of various types and localizations, as well as markers
of radio sensitivity/resistance in the influence of ionizing radiation. The respondents of the research
group were workers of asbestos-cement plants and coal miners in the anamnesis in with bronchopulmonary
pathology, the control group consisted of workers without diseases of the respiratory system. The genotypes
of the genes of the the XRCC7 (rs7003908) and ATM (rs664677) were determined in real time by the
polymerase chain reaction method. As a result of the study, it was established that the minor genotype
ATM•T/T (OR=2.48 95%CI: 1.16-5.31; χ²=6.61; P<0.01) are associat with a risk of bronchopulmonary
pathology. Also, it was found that the dominant allele of ATM•A (OR=0.69; 95% CI: 0.46-1.04), genotypes:
dominant homozygotes АТМ•А/А (ОR=0.83; 95%CI: 0.45-1.54), heterozygotes АТМ•А/Т
(ОR=0.67; 95%CI: 0.38-1.21) cause resistance to bronchopulmonary pathology in workers with
harmful and dangerous working conditions. The analysis of the frequency distribution of the allelic variants
of the gene XRCC7 (rs7003908) suggests that there is no association of this polymorphism with the risk of
developing respiratory diseases. The obtained results to the importance of polymorphism of the ATM gene
(rs664677) for the repair of double-strand DNA ruptures in the development of diseases of the respiratory
system in workers in harmful and dangerous industries.
Keywords:
SNP; XRCC7; ATM; bronchopulmonary pathology
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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