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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 74-81


V.Yu. Prokopyuk1, O.S. Prokopyuk1, I.B. Musatova1, I.V. Sorokina2, O.O. Loginova3, K.V. Somova4

  1. Institute of Cryobiology and Cryomedicine, NAS of Ukraine, Ukraine
  2. Kharkiv National Medical University, Ministry of Health of Ukraine, Ukrine
  3. Kharkiv Medical Academy of Postgraduate Education, Ministry of Health of Ukraine, Ukraine
  4. VP Karazin’s Kharkiv National University, Ukraine


The effect of cryopreserved human placenta fragments (CPF) implantation on female rats’ reproductive system and its function in the period of late ontogenesis was experimentally investigated. The increase of number of growing and mature follicles is educed twice, yellow bodies - in 1,8 time as compared to old falsely-operated females. There was a decline of index of apoptosis of cellular elements of ovaries, to the absorbancy of luminescence of collagen type IV and increase of intensity of luminescence of endotheliocytes that expressed receptors to endothelin- 1. After implantation of CPF of uterus on gravimetric coefficients were similar to such for young females. For the females of basic experimental group the decline of absorbancy of fluorescence of deoxyribonucleotides was observed in the nucleus of epitheliocytes and increase of absorbancy of fluorescence of ribonucleoproteins in the cytoplasm of cells of uteruses, that is the sign of increase of their functional activity, as compared to old falsely-operated females. Thus, implantation of CPF restores tissue of the reproductive system of females of senescent rats, but without proceeding in a reproductive function.

Keywords: late ontogenesis; involutive changes; cryopreserved fragments of placenta; rats; reproductive system.


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