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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 57-65


S.P. Guranych, N.M. Voronych-Semchenko, T.V. Guranych

    Ivano-Frankivsk National Medical University, Ukraine


The changes of indexes of the activity of enzymes of bioenergetic processes, macro- and microelement status of rats with iodine deficiency and insulin resistance were analyzed. It was found that the development of iodine deficiency was accompanied by inhibition of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) activity against the background of increased activity of acid phosphatase (ACP), decreased calcium and magnesium content in solid tissues of teeth and bones in comparison with data in intact animals. The decreased activity of succinate dehydrogenase (SDH) and LDH on the background of increased activity of malate dehydrogenase (MDH) and ACP, decreased calcium and magnesium content in solid tissues of teeth and alveolar processes, increased zinc content in the teeth under the conditions of insulin resistance. It can be assumed that under the conditions of iodine deficiency, the activity of osteoblasts was suppressed, while osteoclasts were more activated in case of insulin resistance. In rats with insulin resistance on the background of iodine deficiency, a significant decrease of dehydrogenase activity in blood serum (on 90.38-97.12 %) was observed as to indexes in intact animals. In erythrocyte mass, teeth and alveolar processes, the content of calcium, magnesium and manganese decreased by 20.26-88.26 % with a simultaneous increase in zinc content in dental tissues at 77.35 %. The violation of calcium homeostasis was conformed with the increase in the activity of ACP (2.42 times), that may be the cause of increased demineralization of teeth and bones in conditions of insulin resistance on the background of iodine deficiency. The determination of the activity of bioenergy synthesis enzymes (SDH, LDH) under conditions of endocrinopathy can be used as one of the early markers of subcellular metabolic disorders of macroenergy formation. The changes of the enzymatic activity of ACP and ALP indicate the progression of bone tissue regeneration processes, which allows to detect disturbances of the mineralization of solid tissues on the early stages of iodine deficiency and insulin resistance development.

Keywords: iodine deficiency; insulin resistance; energy synthesis enzymes; macro- and microelement status.


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