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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 26-32


O.V. Danchuk, V.I. Karpovskyі, V.О. Trokoz

    National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine


The cortical regulation of anti-, prooxidant status in the body of large white pigs with different types of higher nervous activity (HNA) under the influence of stimuli of different etiology has been investigated. The stress factor was the weaning of piglets from a sow, revaccination (biological stimulus) and regrouping and moving (technological stimulus). Before exposure to stimuli and after 1, 5 and 30 days it was taken the blood, sample in which the indexes of lipid peroxide oxidation (LPO) and activity of the antioxidant defense system (ADS) were determined based on which the anti-, prooxidant index (LPO/ADS) was calculated. Regardless of the typological characteristics of HNA, the effects of stimuli of different etiology in pigs developed oxidative stress, which was accompanied by intensification of the LPO and the change in the activity of the enzymes of the ADS. In animals with a strong balanced mobile type a day after the action of technological and biological stimuli an adequate activation of mechanisms of neutralization of free radicals is established: LPO/ADS decreases by 35,6-51,3%. Pigs with a strong balanced inert type slowly adapt to the action of stress factors: after 5 days after the action of the technological stimulus LPO/ADS more than 3 times from such in animals SBMT. In an animal with a strong unbalanced and a weak type under the influence of technological stimuli during the day, the oxidative homeostasis shifts to the side of the intensification of the LPO, which is not compensated by the ADS: LPO/ADS increases 1.4-5.0 times.

Keywords: lipid peroxide oxidation; antioxidant system; lipid peroxide oxidation/antioxidant system; higher nervous activity; pigs; stress.


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