Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 26-32

ANTIOXIDANT-PROOXIDANT STATUS IN ORGANISM OF PIGS WITH DIFFERENT TYPES OF HIGHER NERVOUS ACTIVITY UNDER STRESS

O.V. Danchuk, V.I. Karpovskyі, V.О. Trokoz

    National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.04.026


Abstract

The cortical regulation of anti-, prooxidant status in the body of large white pigs with different types of higher nervous activity (HNA) under the influence of stimuli of different etiology has been investigated. The stress factor was the weaning of piglets from a sow, revaccination (biological stimulus) and regrouping and moving (technological stimulus). Before exposure to stimuli and after 1, 5 and 30 days it was taken the blood, sample in which the indexes of lipid peroxide oxidation (LPO) and activity of the antioxidant defense system (ADS) were determined based on which the anti-, prooxidant index (LPO/ADS) was calculated. Regardless of the typological characteristics of HNA, the effects of stimuli of different etiology in pigs developed oxidative stress, which was accompanied by intensification of the LPO and the change in the activity of the enzymes of the ADS. In animals with a strong balanced mobile type a day after the action of technological and biological stimuli an adequate activation of mechanisms of neutralization of free radicals is established: LPO/ADS decreases by 35,6-51,3%. Pigs with a strong balanced inert type slowly adapt to the action of stress factors: after 5 days after the action of the technological stimulus LPO/ADS more than 3 times from such in animals SBMT. In an animal with a strong unbalanced and a weak type under the influence of technological stimuli during the day, the oxidative homeostasis shifts to the side of the intensification of the LPO, which is not compensated by the ADS: LPO/ADS increases 1.4-5.0 times.

Keywords: lipid peroxide oxidation; antioxidant system; lipid peroxide oxidation/antioxidant system; higher nervous activity; pigs; stress.

Full text: (PDF, in Ukrainian)

References

  1. Karpovskyi PV, Karpovskyi VV, Trokoz AV, Landsman AA, Skrypkina VN, Postoi RV, Kryvoruchko DI, Trokoz VO, Karpovskyi VI. Cortico-vegetative regulation of relations in the physiological functions of pigs. Biolohiia Tvaryn. 2015;17(2):65-73. [Ukrainian].
    2.  
  2. Naumenko VV. Some features of higher nervous activity and types of the nervous system in pigs. [dissertation abstract] Lviv: LNUVM named after S. Z. Gzhytsky. 1968;36. [Russian].
    3.  
  3. Kokorina EP. Conditioned reflexes and productivity of animals. Moscow: Agropromizdat. 1986;335. [Russian].
    4.  
  4. Karpovskyi VI, Trokoz VO, Danchuk OV, Postoi RV, Karpovskyi VV, Vasyliv AP. The influence of the main cortical processes on the productivity of pigs during the period of technological stress. Ekolog i Zhivotn Mir. 2016;2:8-13. [Ukrainian].
    5.  
  5. Antelman SM, Chiodo LA. Stress: its effect on interaction among biogenic amines and role in the induction and treatment of diseases. In Iverson LS, Iverson SD, Snayder SH eds. Handbook of Phychopharmacology, 18th ed. New York: Plenum Press, 1984:279-341. CrossRef  
  6. Kim HL, Plaisant O, Leboyer M et al. Reduction of platelet serotonin in major depression (endogenous depression). C.R. Acad. Sci. III. 1982;295:619-22.
    7.  
  7. Danchuk VV. Processes of lipid peroxidation, hormonal and substrate mechanisms of regulation of antioxidant system in pig tissues [dissertation] Lviv: UAAS, Institute of Animal Biology, 2002;290. [Ukrainian].
    8.  
  8. Danchuk VV, Danchuk AV, Tsepko NL. Oxidative stress - pathology or adaptation? Livestock Ukraine. 2004;4:21-3. [Ukrainian].
    9.  
  9. Gray JI, Monahan FJ. Measurement of lipid oxidation in meat and meat products. Trends Food Sci Technol. 1992;3:315-19. CrossRef  
  10. Vladimirov YA, Azizova OA, Deev AI et al. Free radicals in living systems. The results of science and technology. Ser. Viofizyka. 1991;29.
    11.  
  11. Tarasov II. Stress syndrome in pigs. Agriculture abroad. 1982;4:47-9. [Russian].
    12.  
  12. Lovell MA, Xie C, Markesbery WR. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology. 1998;51(6):1562-6. CrossRef PubMed
    13.  
  13. Tokarchuk KO, Kapustyanenko LG, Shandrenko SG. The role of aldehydes in development of oxidative stress under rhabdomyolysis in rats. Fiziol Zh. 2013;59(1):25-32. [Ukrainian]. PubMed
    14.  
  14. Sahach VF, Andrukhov OIa. The effect of nitric oxide on the contractile activity of skinned preparations of the smooth muscles of the rat portal vein. 2000;46(1):3-9. [Ukrainian].
    15.  
  15. Trokoz VO, Karpovskyi VI, Trokoz AV, Puzir VV, Vasyliv AP, inventors, NULES of Ukraine, assignee. Method of determining the types of higher nervous activity pigs. Ukraine Pat. 70344. 2012 June 11. [Ukrainian].
    16.  
  16. Vlizlo VV, ed. Laboratory research methods in biology, livestock and veterinary medicine: reference book. Lviv: Spolom. 2012;761. [Ukrainian].
    17.  
  17. Trokoz AV. Influence of typological features of the nervous system on the immunological reactivity of the pig's body [dissertation abstract] Kyiv: Nat. Univ. Life Environmen. Sci. Ukraine; 2014;21. [Ukrainian].
    18.  
  18. Danchuk OV, Karpovskyi VI, Trokoz VO, Postoi RV. Regulation mechanisms of cortisol level in pigs' blood serum under stress. Fiziol Zh. 2017;63(6):60-5. [Ukrainian]. CrossRef

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.