Group of eight patients with the temporal lobe epilepsy was examined. During the performance of the motor task the activation of the primary and associative sensorimotor regions of the cerebral cortex, which constitute the sensory motor neural network, was detected. Averaged general volume of activation voxels was 46.22 cm3, with the used threshold value was Z ≥ 2.3. Averaged changes of magnetic resonance (MR) signal in activation clusters were 1.15% (SD = 0.17%). The analysis of the data obtained in the resting state showed the functional connectivity of the regions of the anterior pole of the inferior temporal gyrus, the posterior pole of the middle temporal gyrus, parahippocampal gyri of both hemispheres, as well as the hippocampus of the left hemisphere of the brain, which topographically corresponds to the localization of epileptiform activity according to the electroencephalography. The frequency of oscillation of MRsignal in described neuronal network was 0.1·10-3Hz. Thus, we have discovered the activation of the intact sensorimotor neural network, as well as the functional connectivity of a potentially epileptogenic macroscopic neural network. Consequently, functional magnetic resonance imaging potentially can complement diagnostic methods for detecting epileptogenic neural networks in temporal epilepsy.