Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 12-19


T.A. Andrushchenko1, S.V. Goncharov2, V.E. Dosenko2

  1. State Institution « Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine «, Kyiv, Ukraine
  2. Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine


The studied the frequency distribution of the genotypes genes of the excision repair of bases and nucleotides: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC3 (rs861539) and XRCC1 (rs25487) among workers of hazardous and harmful industries (miners and workers of asbestos cement plants (n=214) to identify markers of risk of bronchopulmonary pathology. In 90 patients with bronchopulmonary pathology and 124 persons working under the same conditions but without respiratory system diseases, the polymerase chain reaction in real time was determined by the polymorphisms of DNA repair genes: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC1 ( rs25487) and XRCC3 (rs861539). As a result of the study, the genotypes associated with the risk of developing bronchopulmonary pathology were as follows: XPD•C/C (rs13181) (Р≤0.04, χ² = 4.11; OR = 2.13; 95% CI: 0.96-4.78), XRCC1•A/A (rs25487) (Р≤0.009, χ2 = 6.73, OR = 3.31, 95% CI: 1.20-9.47). We have determined certain genotypes that may contribute to resistance to the development of these diseases: XPD•A/C (rs13181) (Р≤0.03, χ² = 4.48; OR = 0.55; 95% CI: 0.30- 0.99), XRCC1•G/A (rs25487) (Р≤0.04, χ2 = 4.16; OR = 0.56; 95% CI: 0.31-1.02). The obtained results for indicate the importance of polymorphisms of DNA repair genes in the formation of bronchopulmonary pathology of certain professional groups, which opens the prospects for the development of modern preventive measures.

Keywords: SNP, XPD, ERCC1, XRCC1, XRCC3, bronchopulmonary pathology.


  1. Izmerov NF, Chuchalin AG. Occupational diseases of the respiratory system (National leadership). Moscow. Publish in group "GEOTAR-Media". 2015: 119-48. [Russian].
  3. Izmerov NF, Dinisov EN, Kuzmina LP. Biochemical and genetic indicators of individual sensitivity to occupational hazards: Occupational health risk for workers (guidance). Moscow. Publish in group "Trovant". 2003; 329-34. [Russian].
  5. Pranik NB, Goncharov SV, Gurianova VL, Maidannik VG, Khaitovych MV, Moibenko OO, Dosenko VE. Analysis of Association between 11 Single-Nucleotide Polymorphisms and Endothelium-Dependent Vasodilation in Children with Type 1 Diabetes Mellitus. Fiziol Zh. 2016; 62 (1):43-52. [Ukrainian]. CrossRef PubMed
  7. Savchuk OI, Mel'nyk VS, Goncharov SV, Shandiuk VI, Stroĭ DO, Dosenko VE, Sokolova LI, Skybo HH. Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke. Fiziol Zh. 2014; 60 (1): 49-55. [Ukrainian]. CrossRef PubMed
  9. Urzhumov PV, Pogodina AV, Akleev AV. Polymorphisms of NBS1 and PARP1 genes and the efficiency of DNA repair: Bull Chelyabinsk State Univer. 2013; 7 (298): 107-8. [Russian].
  11. Kiffmeyer WR, Langer E, Davies SM. Envall J, Robison LL, Ross JA. Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival. Cancer. 2004; 100 (2): 411-7. CrossRef PubMed
  13. Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A. Variants in double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 2002. (11): 1399-440. CrossRef PubMed
  15. Pavanello S, Clonfero E. Individual susceptibility to occupational carcinogens: the evidence from biomonitiring and molecular epidemiology studies. G Ital Med Lav Ergon. 2004 Oct-Dec; 26(4): 311- 21. PubMed
  17. Shin A, Lee KM, Ahn B, Park CG, Noh SK. et al. Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity. Asian Pac J Cancer Prev 2008; 9:501-5. PubMed
  19. Andrushchenko TA, Goncharov SV, Dosenko VE. The study of XPD gene polymorphism in workers of asbestos-cement plants in Ukraine. Biological Markers in Fundamental and Clinical Medicine (collection of abstracts) 2; 1: 69-70.
  21. Zienolddiny S, Campa D, Lind H. et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006; 27 (3): 560-7. CrossRef PubMed
  23. Hao B, Miao X, Li Y, Zhang X, Sun T, et al. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of nonsmall cell lung cancer. Oncogene, 25. 2006: 3613-20. CrossRef PubMed
  25. Wang Y, Yang H, Li H, Li L, Wang H. et al. Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: a meta-analysis. Cancer. 2009; 285: 134-40. CrossRef  
  26. Rodriguez S, Gaunt TR, Day NM. Hardy-Weinberg Equilibrium Testing of Ascertainment for Mendelian Randomization Studies. American J Biol Epidemiol. 2009; 10: 1093- 359. CrossRef  
  27. Bukowski K, Wozniak K. Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides. Med. Pr. 2017. Oct. 12:758-79.
  29. Bohanes P, Labonte MJ, Lenz HJ. A review of excision repair cross-complementation group 1 in colorectal cancer. Clin Colorectal Cancer. 2011; 10: 157- 64. CrossRef PubMed
  31. Todd RC, Lippard SJ. Inhibitor of transcription by platinum antitumor compounds. Mellallomics. 2009; 1: 280-91. CrossRef PubMed PubMedCentral

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.