GENETIC PREDISPOSITION TO BRONCHOPULMONARY PATHOLOGY IN WORKERS OF HARMFUL AND HAZARDOUS INDUSTRIES: ANALYSIS OF FIVE POLYMORPHISMS OF DNA GENE REPAIR
T.A. Andrushchenko1, S.V. Goncharov2, V.E. Dosenko2
- State Institution « Kundiiev Institute of Occupational
Health of the National Academy of Medical Sciences of
Ukraine «, Kyiv, Ukraine
- Bogomoletz Institute of Physiology of the National Academy
of Sciences of Ukraine, Kyiv, Ukraine
The studied the frequency distribution of the genotypes genes
of the excision repair of bases and nucleotides: XPD (rs13181,
rs799793), ERCC1 (rs11615), XRCC3 (rs861539) and XRCC1
(rs25487) among workers of hazardous and harmful industries
(miners and workers of asbestos cement plants (n=214) to
identify markers of risk of bronchopulmonary pathology.
In 90 patients with bronchopulmonary pathology and 124
persons working under the same conditions but without
respiratory system diseases, the polymerase chain reaction
in real time was determined by the polymorphisms of DNA
repair genes: XPD (rs13181, rs799793), ERCC1 (rs11615),
XRCC1 ( rs25487) and XRCC3 (rs861539). As a result of the
study, the genotypes associated with the risk of developing
bronchopulmonary pathology were as follows: XPD•C/C
(rs13181) (Р≤0.04, χ² = 4.11; OR = 2.13; 95% CI: 0.96-4.78),
XRCC1•A/A (rs25487) (Р≤0.009, χ2 = 6.73, OR = 3.31, 95%
CI: 1.20-9.47). We have determined certain genotypes that may
contribute to resistance to the development of these diseases:
XPD•A/C (rs13181) (Р≤0.03, χ² = 4.48; OR = 0.55; 95% CI:
0.30- 0.99), XRCC1•G/A (rs25487) (Р≤0.04, χ2 = 4.16; OR =
0.56; 95% CI: 0.31-1.02). The obtained results for indicate
the importance of polymorphisms of DNA repair genes in the
formation of bronchopulmonary pathology of certain professional
groups, which opens the prospects for the development
of modern preventive measures.
SNP, XPD, ERCC1, XRCC1, XRCC3, bronchopulmonary pathology.
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