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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(4): 12-19


GENETIC PREDISPOSITION TO BRONCHOPULMONARY PATHOLOGY IN WORKERS OF HARMFUL AND HAZARDOUS INDUSTRIES: ANALYSIS OF FIVE POLYMORPHISMS OF DNA GENE REPAIR

T.A. Andrushchenko1, S.V. Goncharov2, V.E. Dosenko2

  1. State Institution « Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine «, Kyiv, Ukraine
  2. Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.04.012

Abstract

The studied the frequency distribution of the genotypes genes of the excision repair of bases and nucleotides: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC3 (rs861539) and XRCC1 (rs25487) among workers of hazardous and harmful industries (miners and workers of asbestos cement plants (n=214) to identify markers of risk of bronchopulmonary pathology. In 90 patients with bronchopulmonary pathology and 124 persons working under the same conditions but without respiratory system diseases, the polymerase chain reaction in real time was determined by the polymorphisms of DNA repair genes: XPD (rs13181, rs799793), ERCC1 (rs11615), XRCC1 ( rs25487) and XRCC3 (rs861539). As a result of the study, the genotypes associated with the risk of developing bronchopulmonary pathology were as follows: XPD•C/C (rs13181) (Р≤0.04, χ² = 4.11; OR = 2.13; 95% CI: 0.96-4.78), XRCC1•A/A (rs25487) (Р≤0.009, χ2 = 6.73, OR = 3.31, 95% CI: 1.20-9.47). We have determined certain genotypes that may contribute to resistance to the development of these diseases: XPD•A/C (rs13181) (Р≤0.03, χ² = 4.48; OR = 0.55; 95% CI: 0.30- 0.99), XRCC1•G/A (rs25487) (Р≤0.04, χ2 = 4.16; OR = 0.56; 95% CI: 0.31-1.02). The obtained results for indicate the importance of polymorphisms of DNA repair genes in the formation of bronchopulmonary pathology of certain professional groups, which opens the prospects for the development of modern preventive measures.

Keywords: SNP, XPD, ERCC1, XRCC1, XRCC3, bronchopulmonary pathology.

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