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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(3): 79-90


O. Pogorielova, V. Garbuzova, L. Prystupa, A. Fadeeva

    Sumy State University, Sumy, Ukraine


The aim of our work was the systematization of information on the role of MMP-3, -8, -9 in the pathogenesis of atherosclerosis, atherosclerotic plaque destabilization and analysis of currently available sources (PubMed, ScienceDirect) on the association of polymorphisms (5A/6A, C-799→Т, С-1562→Т) with the development of chronic coronary artery disease (CAD) and acute coronary syndrome (ACS) in representatives of different populations. The results of our studies revealed the association of the T-allel C-1562→T-polymorphism of MMP-9 gene with development and progression of atherosclerosis in Chinese, Iranian, French, British, and Indonesian populations. The literature data confirmed the association of the 5A/5A-genotype of the 5A/6A-polymorphism of MMP-3 gene with the severity and volume of atherosclerotic lesion of the coronary arteries in Japanese population, the coronary artery calcification in older male Finns, and the association of 6A/5A and 5A/5A-genotypes with development of carotid atherosclerosis and stable forms of IHD in representatives of Russian and Turkish populations. The association of C-799→T of MMP-8 polymorphism with the development of IHD in representatives of the Finnish and Chinese populations was proved. The actuality, necessity and perspective of the study as a genetic component of IHD development in representatives of Ukrainian population are shown.

Keywords: coronary artery disease; acute coronary syndrome; matrix metalloproteinases; gene polymorphism


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