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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(3): 79-90


THE ROLE OF MATRIX METALLOPROTEINASES AND POLYMORPHISMS OF THEIR GENES IN THE DEVELOPMENT OF CORONARY HEART DISEASE

O. Pogorielova, V. Garbuzova, L. Prystupa, A. Fadeeva

    Sumy State University, Sumy, Ukraine
DOI: https://doi.org/10.15407/fz64.03.079

Abstract

The aim of our work was the systematization of information on the role of MMP-3, -8, -9 in the pathogenesis of atherosclerosis, atherosclerotic plaque destabilization and analysis of currently available sources (PubMed, ScienceDirect) on the association of polymorphisms (5A/6A, C-799→Т, С-1562→Т) with the development of chronic coronary artery disease (CAD) and acute coronary syndrome (ACS) in representatives of different populations. The results of our studies revealed the association of the T-allel C-1562→T-polymorphism of MMP-9 gene with development and progression of atherosclerosis in Chinese, Iranian, French, British, and Indonesian populations. The literature data confirmed the association of the 5A/5A-genotype of the 5A/6A-polymorphism of MMP-3 gene with the severity and volume of atherosclerotic lesion of the coronary arteries in Japanese population, the coronary artery calcification in older male Finns, and the association of 6A/5A and 5A/5A-genotypes with development of carotid atherosclerosis and stable forms of IHD in representatives of Russian and Turkish populations. The association of C-799→T of MMP-8 polymorphism with the development of IHD in representatives of the Finnish and Chinese populations was proved. The actuality, necessity and perspective of the study as a genetic component of IHD development in representatives of Ukrainian population are shown.

Keywords: coronary artery disease; acute coronary syndrome; matrix metalloproteinases; gene polymorphism

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