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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(3): 52-60


O.I. Belikova1, V.S. Cherno1, Yu.D. Frenkel’1, V.O. Kostenko2

  1. V.O. Sukhomlinsky Mykolayiv National University. Ukraine
  2. Ukrainian Medical Stomatological Academy, Poltava, Ukraine


We studied the effect of hypomelatoninemia induced by round-the-clock light with an intensity of 1500 lx for 60 days on carbohydrate and lipid metabolism of white rats kept on high-calorie carbohydrate-lipid diet (HCCLD, 20 % fructose solution and the diet). It was found that these conditions reduced the melatonin concentration in the blood serum by 55.6 % compared with the results obtained from the animals exposed to the round-the clock light only. Herewith, the animals developed the insulin resistance syndrome, which was accompanied by more marked manifestations of its characteristic metabolic symptoms as hyperinsulinemia, dyslipoproteinemia, hypo-α-lipoproteinemia, hypertrialcylglycerolemia, and increased visceral fat mass. This condition demonstrated the development of decompensated lipid peroxidation and a decrease in the antioxidant potential in the blood of rats, but without significant changes in the concentration of systemic inflammation markers (tumor necrosis factor α and ceruloplasmin). Under these circumstances the formation of secondary peroxidation products (compounds reacting with thiobarbituric acid) surpassed the relevant results in the group exposed to the separate round-the-clock light and in the group kept on the high-calorie carbohydrate-lipid diet by 49.1 % and 11.9 % respectively.

Keywords: insulin resistance syndrome; hypomelatoninemia; high-calorie carbohydrate-lipid diet; carbohydrate and lipid metabolism; systemic inflammatory response


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