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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(3): 52-60

INFLUENCE OF CHRONIC HYPOMELATONINEMIA ON CARBOHYDRATE AND LIPID METABOLISM OF RATS KEPT ON WESTERN DIET

O.I. Belikova1, V.S. Cherno1, Yu.D. Frenkel’1, V.O. Kostenko2

  1. V.O. Sukhomlinsky Mykolayiv National University. Ukraine
  2. Ukrainian Medical Stomatological Academy, Poltava, Ukraine
DOI: https://doi.org/10.15407/fz64.03.052


Abstract

We studied the effect of hypomelatoninemia induced by round-the-clock light with an intensity of 1500 lx for 60 days on carbohydrate and lipid metabolism of white rats kept on high-calorie carbohydrate-lipid diet (HCCLD, 20 % fructose solution and the diet). It was found that these conditions reduced the melatonin concentration in the blood serum by 55.6 % compared with the results obtained from the animals exposed to the round-the clock light only. Herewith, the animals developed the insulin resistance syndrome, which was accompanied by more marked manifestations of its characteristic metabolic symptoms as hyperinsulinemia, dyslipoproteinemia, hypo-α-lipoproteinemia, hypertrialcylglycerolemia, and increased visceral fat mass. This condition demonstrated the development of decompensated lipid peroxidation and a decrease in the antioxidant potential in the blood of rats, but without significant changes in the concentration of systemic inflammation markers (tumor necrosis factor α and ceruloplasmin). Under these circumstances the formation of secondary peroxidation products (compounds reacting with thiobarbituric acid) surpassed the relevant results in the group exposed to the separate round-the-clock light and in the group kept on the high-calorie carbohydrate-lipid diet by 49.1 % and 11.9 % respectively.

Keywords: insulin resistance syndrome; hypomelatoninemia; high-calorie carbohydrate-lipid diet; carbohydrate and lipid metabolism; systemic inflammatory response

Full text: (PDF, in Ukrainian)

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