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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(3): 37-42


THE EFFECT OF VANADIUM CITRATE ON HAEMATOLOGICAL CHARACTERISTICS OF RATS UNDER ALLOXAN-INDUCED DIABETES

L. Ponkalo, H. Klymets, R. Iskra, O. Sushko

    Institute of Animal Biology of NAAS, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz64.03.037

Abstract

The effect of vanadium citrate on the haematological indexes of the alloxan-induced diabetic rats was studied. It was established that in animals of the II group which consumed pure water, the number of leukocytes apparently increased by 50.24%, platelets – by 56.94%, and the hemoglobin concentration - by 11.87% as compared to the control. In addition, in animals of this group, the mean cell volume increased, which was accompanied by a decrease in the mean corpuscular hemoglobin concentration. It was found that the consumption of vanadium citrate at doses of 0,125, 0,5, і 2 µg/ml under alloxan-induced diabetes resulted in the normalization of rats’ haematological profile indexes, particularly the number of leukocytes decreased by 20.49, 12.36 and 29.14 % respectively, as compared to the control group II. In animals treated with vanadium citrate at doses of 0,125 and 0,5 µg/ml, it was shown an apparent decrease in the number of platelets by 55.83 and 51.92 %, the magnitude of hematocrit by 23,79 and 14,20 %, thrombocrit by 27,29 and 58,25 % and hemoglobin concentration by 24,97 аnd 13,98 %, while these parameters reached almost control values.

Keywords: diabetes; vanadium citrate; blood; alloxan; rats

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