The experiments conducted on laboratory non-linear albino mature male rats with a quick type of acetylation examined renal function under conditions of cadmium-nitrate intoxication. A combined introduction of cadmium chloride (0.1 mg/kg intraperitoneally) and sodium nitrate (500 mg/kg intragastrically) during 14 days was found to result in 31.2 % increase of glomerular filtration rate (GFR). Due to increased GFR volume regulating, excretory kidney functions are activated that was assessed by endogenic creatinine clearance. In case of lack of hypercreatininemia the concentration of creatinine in the urine 16.5 % increased, creatinine excretion became 31.8 % higher. Concentration of sodium ions in the urine 67.8 % decreased, and excretion with urine decreased three times as much. Concentration of sodium ions in the blood plasma 6.6 % decreased. Al though renal regulation of sodium ions metabolism was not disturbed: distal reabsorption did not change, proximal reabsorption 24.4 % increased. Retention of tubular mechanisms of sodium metabolism regulation and glomerular-tubular balance are indicative of adaptive possibilities of the kidneys of mature rats with a quick type of acetylation ensuring maintenance of water-electrolytic balance under conditions of subacute cadmium-nitrate effect. Further investigations of the effect of a combined action of cadmium chloride and sodium nitrate on mature rats with slow acetylation and comparative analysis of the renal function are of great importance in order to assess a prognostic value of acetylation phenotype in the development of nephropathy