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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(6): 24-29

Activity of elastase and its inhibitors in tissuesof aorta and blood serum in different types of acidosis

І.M.Trofimova, V.E.Dosenko, YU.V.Byts

    A.A. Bogomoletz National Medical University,Kiev



Abstract

In modeling of different types of acidosis (hyper- chloraemic, lactate and ketoacidosis in the starvation) at rats the elastase activity, contents of alpha-2 macro- globulin (alpha2М) and alpha-1 proteinase inhibitor (alpha1PI) in aorta tissues and blood serum were studied. The obtained results indicate that the degree of disturbance in system elastase - inhibitors depends on expressiveness of parameters changes in system of acid-base state regulation. In modeling of various types of acidosis coefficient inhibitors / elastase is reduced due to different parameters change in aorta, namely decrease of alpha2М contents – in hyperchloraemic acidosis, increase of elastase activity - in lactat- acidosis, increase of elastase activity and decrease of alpha2М contents - in ketoacidosis. In blood serum the similar coefficient is reduced due to increase of elastase activity and decrease of alpha2М contents in hyperchloraemic acidosis and starvation, and, in turn, due to decrease of alpha2М contents - in lactat-acidosis. The obtained data indicate that one of mechanisms of vascular wall damage in acidosis is disturbance of balance between elastase and its inhibitors in tissues of arteries.

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