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EFFECT OF ISCHEMIC AREA OF THE BRAIN REPERFUSION ON THE FUNCTIONAL STATE OF THE HEART
R.R. Sharipov , N.А. Dorofeyeva , V.F. Sagach
O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.02.090
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Abstract
Changes in rats’ cardioghemodynamics on the isolated occlusion
and reperfusion of the middle cerebral artery model were
investigated, using the ultra-miniature catheter 2F (“Millar
Instruments”, USA). In vivo experiments was found that
reperfusion of the brain led to decreasing in the parameters
of myocardial contractile activity (reduction of dP/dt max by
25.4%) and pumping function of the heart (stroke volume decreased
by 32.6%, cardiac output by 43.3%). Positive changes
in the diastolic function of the heart during early reperfusion
and after 24 hours (reduction of end-diastolic myocardial
stiffness and increasing in dP/dt min) were shown. A day later,
recovery of the myocardium contractile activity (normalization
of dP/dt max), pumping function (stroke volume and cardiac
output increased by 2 times) and partial improvement of the
heart diastolic function were observed. Thus, there is a significant
decrease in the myocardium contractile activity and
heart pumping function during early brain reperfusion, which
is partially restored after 24 hours.
Keywords:
focal cerebral reperfusion, cerebrocardial syndrome, cardiohemodynamic
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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