Changes in rats’ cardioghemodynamics on the isolated occlusion and reperfusion of the middle cerebral artery model were investigated, using the ultra-miniature catheter 2F (“Millar Instruments”, USA). In vivo experiments was found that reperfusion of the brain led to decreasing in the parameters of myocardial contractile activity (reduction of dP/dt max by 25.4%) and pumping function of the heart (stroke volume decreased by 32.6%, cardiac output by 43.3%). Positive changes in the diastolic function of the heart during early reperfusion and after 24 hours (reduction of end-diastolic myocardial stiffness and increasing in dP/dt min) were shown. A day later, recovery of the myocardium contractile activity (normalization of dP/dt max), pumping function (stroke volume and cardiac output increased by 2 times) and partial improvement of the heart diastolic function were observed. Thus, there is a significant decrease in the myocardium contractile activity and heart pumping function during early brain reperfusion, which is partially restored after 24 hours.