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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 90-95


EFFECT OF ISCHEMIC AREA OF THE BRAIN REPERFUSION ON THE FUNCTIONAL STATE OF THE HEART

R.R. Sharipov , N.А. Dorofeyeva , V.F. Sagach

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.02.090


Abstract

Changes in rats’ cardioghemodynamics on the isolated occlusion and reperfusion of the middle cerebral artery model were investigated, using the ultra-miniature catheter 2F (“Millar Instruments”, USA). In vivo experiments was found that reperfusion of the brain led to decreasing in the parameters of myocardial contractile activity (reduction of dP/dt max by 25.4%) and pumping function of the heart (stroke volume decreased by 32.6%, cardiac output by 43.3%). Positive changes in the diastolic function of the heart during early reperfusion and after 24 hours (reduction of end-diastolic myocardial stiffness and increasing in dP/dt min) were shown. A day later, recovery of the myocardium contractile activity (normalization of dP/dt max), pumping function (stroke volume and cardiac output increased by 2 times) and partial improvement of the heart diastolic function were observed. Thus, there is a significant decrease in the myocardium contractile activity and heart pumping function during early brain reperfusion, which is partially restored after 24 hours.

Keywords: focal cerebral reperfusion, cerebrocardial syndrome, cardiohemodynamic

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