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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 90-95


R.R. Sharipov , N.А. Dorofeyeva , V.F. Sagach

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


Changes in rats’ cardioghemodynamics on the isolated occlusion and reperfusion of the middle cerebral artery model were investigated, using the ultra-miniature catheter 2F (“Millar Instruments”, USA). In vivo experiments was found that reperfusion of the brain led to decreasing in the parameters of myocardial contractile activity (reduction of dP/dt max by 25.4%) and pumping function of the heart (stroke volume decreased by 32.6%, cardiac output by 43.3%). Positive changes in the diastolic function of the heart during early reperfusion and after 24 hours (reduction of end-diastolic myocardial stiffness and increasing in dP/dt min) were shown. A day later, recovery of the myocardium contractile activity (normalization of dP/dt max), pumping function (stroke volume and cardiac output increased by 2 times) and partial improvement of the heart diastolic function were observed. Thus, there is a significant decrease in the myocardium contractile activity and heart pumping function during early brain reperfusion, which is partially restored after 24 hours.

Keywords: focal cerebral reperfusion, cerebrocardial syndrome, cardiohemodynamic


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