Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 90-95


EFFECT OF ISCHEMIC AREA OF THE BRAIN REPERFUSION ON THE FUNCTIONAL STATE OF THE HEART

R.R. Sharipov , N.А. Dorofeyeva , V.F. Sagach

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.02.090

Abstract

Changes in rats’ cardioghemodynamics on the isolated occlusion and reperfusion of the middle cerebral artery model were investigated, using the ultra-miniature catheter 2F (“Millar Instruments”, USA). In vivo experiments was found that reperfusion of the brain led to decreasing in the parameters of myocardial contractile activity (reduction of dP/dt max by 25.4%) and pumping function of the heart (stroke volume decreased by 32.6%, cardiac output by 43.3%). Positive changes in the diastolic function of the heart during early reperfusion and after 24 hours (reduction of end-diastolic myocardial stiffness and increasing in dP/dt min) were shown. A day later, recovery of the myocardium contractile activity (normalization of dP/dt max), pumping function (stroke volume and cardiac output increased by 2 times) and partial improvement of the heart diastolic function were observed. Thus, there is a significant decrease in the myocardium contractile activity and heart pumping function during early brain reperfusion, which is partially restored after 24 hours.

Keywords: focal cerebral reperfusion, cerebrocardial syndrome, cardiohemodynamic

References

  1. Benerjee A, Silver L.E, Heneghan C et al. Populationbased comparison of risk factors for ischaemic stroke versus acute coronary syndromes: identical twins or distant relatives? Cerebrovascular diseases/Abstracts of 17th European Stroke conference, Nice, France 2008; 25:16.
  2.  
  3. Hyvdrinen M, Qiao Q, Tuomilehto J et al. The difference between acute coronary heart disease and ischaemic stroke risk with regard to gender and age in Finnish and Swedish population. Inte J Stroke. 2010; 5(3):152-6. CrossRef PubMed
  4.  
  5. Fonyakin AV, Geraskina LA, Trunova ES. Approaches to the prediction of cardiac complications in the post-stroke period. First National Congress 'Stroke and vascularbrain disease' materials 2006; 70-1. [Ukrainian].
  6.  
  7. KentTA, Soukup VM, Fabian RH. Heterogeneity affecting outcome from acute stroke therapy: making reperfusion worse. Stroke. 2001; 32(10):2318-27. CrossRef  
  8. Hata K, Whittaker P, Kloner RA, Przyklenk K. Brief antecedent ischemia attenuates platelet-mediated thrombosis in damaged and stenotic canine coronary arteries: role of adenosine. Circulation. 1998 Feb 24;97(7):692-702. CrossRef PubMed
  9.  
  10. Sharipov RR, Kotsiuruba AV, Kopyak BS, Sagach VF. Induction of oxidative stress in heart mitochondria by focal ischemia – reperfusion brain and protective effect of ecdysterone. Fiziol Zh. 2014; 60(3):11-7. [Ukrainian]. PubMed
  11.  
  12. Sharipov RR, Kotsiuruba AV, Kopyak BS, Sagach VF. Induction of nitrosative stress in mitochondria of rats hearts in experimental ischemia –reperfusion of the brain and itscorrection by ecdysterone. Fiziol Zh. 2014; 60(5):3-13. [Ukrainian]. PubMed
  13.  
  14. Traystman RJ. Animal models of focal and global cerebral ischemia. ILAR J. 2003; 44(2):85-95. CrossRef PubMed
  15.  
  16. Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA. Measurement of cardiac function using pressure volume conductance catheter technique in mice and rats. Nat Protoc. 2008; 9:1422-34. CrossRef PubMed PubMedCentral
  17.  
  18. Back T, Schüler OG. The natural course of lesion development in brain ischemia. Acta Neurochir Suppl. 2004;89:55-61. CrossRef  
  19. Kotsuruba AV, Sharipov RR, Kopyak BS, Sagach VF. Brain focal ischemia-reperfusion causes a decreased resistaince of erythrocytes from venous blood to acid hemolysis, which is prevented ecdysterone. Fiziol Zh. 2015; 61(5):3-10. [Ukrainian]. CrossRef  
  20. Shchokina EG. Study of the cardioprotective features of the recombinant antagonist interleukin-1 receptors under conidtions of the adrenal myocarditis in rats. Ukr J Biopharmaceutical. 2012; (5-6):47-51. [Ukrainian].
  21.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.