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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 71-79


A. I. Bereznyakova1, V. F. Cheremisina1, O.D. Zhemela2, G.P. Guchenko1

  1. National University of Pharmacy, Kharkiv, Ukraine
  2. National University of them N.V. Karazin, Kharkiv, Ukraine


Phase changes in the connective tissue of rats in response to local injury are both local and generalized. The stage of the processes occurring in the far inflammation of the organs corresponds to the classical pattern of development of the inflammatory reaction: at the early stages - the predominance of exudative phenomena, which at a later date (two days) change on proliferation. The secretory activity of mast cells, the granulosis index of mastocytes of the connective tissue of the stomach increased 1.7 times, and the optical density decreased. On day 2, the content of leukocytes and the number of macrophages of the connective tissue of the stomach was significantly lower than the values in the control and decreased by 1.6 times in relation to the 6-hour indicators. Indicators of mast cells were restored to the control group values. The obtained results indicate that with local inflammation the condition of the intercellular substance of the connective tissue. Along with the answer from the cells of the immune system - leukocytes, macrophages, mast cells, there are generalized changes on the part of cells of the fibroblastic series - increasing their number, increasing collagen production, and changing the proliferative potential.

Keywords: acute inflammation; connective tissue; fibroblasts; macrophages; mast cells; collagen


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