Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 71-79


A. I. Bereznyakova1, V. F. Cheremisina1, O.D. Zhemela2, G.P. Guchenko1

  1. National University of Pharmacy, Kharkiv, Ukraine
  2. National University of them N.V. Karazin, Kharkiv, Ukraine


Phase changes in the connective tissue of rats in response to local injury are both local and generalized. The stage of the processes occurring in the far inflammation of the organs corresponds to the classical pattern of development of the inflammatory reaction: at the early stages - the predominance of exudative phenomena, which at a later date (two days) change on proliferation. The secretory activity of mast cells, the granulosis index of mastocytes of the connective tissue of the stomach increased 1.7 times, and the optical density decreased. On day 2, the content of leukocytes and the number of macrophages of the connective tissue of the stomach was significantly lower than the values in the control and decreased by 1.6 times in relation to the 6-hour indicators. Indicators of mast cells were restored to the control group values. The obtained results indicate that with local inflammation the condition of the intercellular substance of the connective tissue. Along with the answer from the cells of the immune system - leukocytes, macrophages, mast cells, there are generalized changes on the part of cells of the fibroblastic series - increasing their number, increasing collagen production, and changing the proliferative potential.

Keywords: acute inflammation; connective tissue; fibroblasts; macrophages; mast cells; collagen


  1. Nicholskiy I. The reaction of the blood system in hypoxia and circulation of hematopoietic stem cells. Environment and Health. 2012;2:79-80.
  3. Babaeva A. Regeneration and system of immunogenesis. M.: Medicine. 1985: 255. [Russian].
  5. Yushkov B, Abidov M, Danilova I et al. Non-immunological functions of macrophages. Ekaterinburg: UrO RAN. 2011: 246. [Russian].
  7. Artashyan O, Yushkov B, Mukhlynina E. Study of the functional activity of mast cells under immobilization stress. Cytology. 2006; 48 (8):665-8. [Russian].
  9. Gusev E, Chereshnev V, Yurchenko L. System inflammation from position of typical pathological process theory. Cytokine and inflammation. 2007; 6 (4):9-21. [Russian].
  11. Reznikov O, Solovyov A, Stefanov O. Biotic examination of preclinical and other scientific researches carried out on animals: method. Bulletin of Pharmacology and Pharmacy. 2006; 7:47-61. [Ukrainian].
  13. Ataman O. Pathophysiology. General pathology. Textbook for Higher Educational Institutions. Kyiv: New Book. 2006; 592. [Ukrainian].
  15. Wagner D, Young V, Tannenbaum S. Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment. Proc. Natl. Acad. Sci. USA. 1983; 80:4518-21. CrossRef  
  16. Korkushko O, Pisaruk A, Asanov E et al. Changes in blood oxygen function in arterial hypoxemia in elderly and senile people. Bukovynska medichny News. 2011;3(59):200-4. [Ukrainian].
  18. Ellinidi V, Anikeeva N, Maksimova N. Practical immunohisto-cytochemistry. Methodical recommendations. SPb.: VCERM RME of Russia. 2002; 36 p. [Russian]
  20. Chrishan S. Determination of collagen content, concentration and sub-types in kidney tissue. Kidney Research: Experimental Protocols. NY: A Humana Press. 2008; 16:223-35.
  22. General ethical principles of animal experiments: materials of the First National Congress on Bioethics. 2001. K: NASU. 16. [Ukrainian].
  24. Gubler E, Genkin A. The application of nonparametric criteria for statistics in biomedical research. L.: Medicine. 1973; 141. [Russian].
  26. Zupan J, Komadina R, Marc J. The relashionship between osteoclastogenic andati-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues. J Biomed Sci. 2012;19:28-32. CrossRef PubMed PubMedCentral
  28. Gordon S, Taylor P. Monocyte and macrophage heterogeneity. Nat. Rev.Immunol. 2005; 5:953-64. CrossRef PubMed
  30. Freidlin I, Totolyan A. Cells of immune system. SPb: Science. 2001; 3:197.
  32. Nascimento M, Hayashi S, Riella M et al. Elevated levels of plasma osteoprotegerin are associated with all-cause mortality risk and atherosclerosis in patients with stages 3 to 5 chronic kidney disease. Braz J Med Biol Res. 2014;22:1-8. CrossRef  
  33. Garbuzenko E, Nagler A, Pickholtz D et al. Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis. Clin. Exp. Allergy. 2002; 32(2):237-146. CrossRef PubMed

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.