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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 47-53


SYSTEMIC EFFECTS OF INFLAMMATION IN ACUTE AND CHRONIC ABDOMINAL DISEASES

V.M. Akimova, L.E. Lapovets

    Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz64.02.047

Abstract

The serum content of interleukines (IL) IL1β, IL6, IL8, tumor necrosis factor (TNF-α), soluble form of TNF-α receptor R1 (sTNF-α-R1), C-reactive protein (CRP), prokalcitonin in patients with acute and chronic inflammation in the abdomen was investigated. Established that in acute mesadenitis the level of TNF-α, IL1β, IL6, IL8 level increased within 5-20 pg/ml. In acute phlegmonous appendicitis IL1β increased at 20 times, IL8 – in 24 times, prokalcitonin – 40 times CRP – 11 times relative to control. Gangrenous form of acute appendicitis is characterized by increased level of TNF-α 7 times, IL8 – in 20 times, СRP – 19 times, prokalcitonin – 374 times higher then control. In abdominal tuberculosis the level of TNF-α increased 3 times, IL1β in 5 times, IL8 – 8 times relative to control. The integrated determining of cytokine profile in patients with chronic and acute diseases of the abdominal cavity is promising to improve differential diagnosis.

Keywords: cytokines; acute inflammation; abdominal tuberculosis; C-reactive protein; proсalcitonin

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