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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 34-39


Circulating in the blood desquamated endotheliocytes at the diabetic nephropathy

A.I. Gozhenko, H.S. Kuznetsova, K.S. Kuznetsova, T.M. Byts, E.A. Gozhenko, N.O. Shevchenko

    State Enterprise “Ukrainian Research Institute of Transport Medicine, Ministry of Health of Ukraine”, Odessa, Ukraine
DOI: https://doi.org/10.15407/fz64.02.034

Abstract

The aim of the study was to determine the role of endothelial dysfunction (ED) in the pathogenesis of diabetic nephropathy (DN) in patients with diabetes mellitus (DM) 1 and 2 type with a severe course (state of decompensation). DN was manifested by a decrease in GFR and urinary syndrome. In patients with diabetes, depending on the glomerular filtration rate (GFR), ED was estimated by the number of circulating desquamation endothelial cells (CECs) with the simultaneous determination of NO2 - and NO3 - metabolites. The indicators of the urinary syndrome don’t correlate with the degree of GFR reduction. The concentration of CECs in blood plasma in patients with GFR ≥ 90 ml.min-1.1.73 m-2 was 3053 ± 210.1 cells/ml. The level of endotheliocythemia in patients with GFR from 42 to 88 ml.min-1.1.73 m-2 was 22 % higher and amounted to 3700 ± 260.6 cells/ml. Therefore, in the patients with DN, the number of CECs in blood plasma increases.

Keywords: diabetes mellitus; endothelial dysfunction; diabetic nephropathy; circulating endothelial cells; glomerular filtration rate; vascular endothelium; nitric oxide

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