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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(2): 3-11

Nanoceria alleviate oxidative and nitrosative stress in salivary glands glutamate-induced obesity rats

L.P. Hordiienko1, T.V. Beregova1, K.S. Neporada2, T.M. Falalyeyeva1, N.M. Zholobak3, O.B. Shcherbakov3, R.V. Bubnov3, M.Ya. Spivak3

  1. Taras Shevchenko National University of Kyiv, Ukraine
  2. HSEE of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava, Ukraine
  3. Zabolotny Institute of Microbiology and Virology, Ukraine


The aim was to study the effects of nanoceria on pro / antioxidant balance in the tissues of salivary glands in glutamate (MSG)-induced obese rats. We included 48 Wistar rats of both genders and divided into four groups, and conducted comparative assessment of intragastric administration of nanocrystalline cerium dioxide at a dose of 1 mg/kg at the background of glutamate-induced obesity. We determined the total activity of NО-synthase, the maintenance of nitrites, the content of TBA-reactive substances, the content of oxidative modified proteins and catalase activity in the homogenate of salivary glands’ tissues of rats. Intragastric administration of nanocrystalline cerium dioxide prevents impairment of pro/antioxidant equilibrium in the tissues of salivary glands of rats on the background of MSG-indused obesity. Intragastric administration of nanocrystalline cerium dioxide on the background of MSG-indused obesity significantly reduces the total NO-synthase activity and the nitrate anions content in salivary gland tissues of rats compared to the group of animals without correction. MSG-induced obesity leads to oxidative stress development in the salivary glands of rats. Administation of nanoceria contributes to the correction of pathological changes in salivary glands via restoring pro/antioxidant balance and preventing the activation of NO-ergic system.

Keywords: nanocrystalline cerium dioxide; obesity; salivary glands; oxidative stress; obesity complications; monosodium glutamate; food additives; animal model.


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