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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 103-117


IMMUNOBIOLOGICAL PROPERTIES OF NEUROGENIC CELLS OF THE FETAL BRAIN. ІI. IMMUNE RESPONSES TO NEUROGENIC STEM CELLS IN VITRO AND IN VIVO

L.D. Liubich, M.I. Lisyany

    SI “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.103

Abstract

The review presents an analysis of the current state of development of the problem of the brain neurogenic stem and progenitor cells (NSC/NPC) immunobiological properties. In section II the data on immune responses in vitro in cocultivation of NSC/NPC and immune system cells, as well as features of the development of immune responses in vivo after NSC/NPC transplantation are given. The transformation of the notions of the immune response in CNS during NSC/NPC transplantation is considered: from the concept of “absolute immuno-privilege” of the brain to the concept of “functional” or “therapeutic plasticity”, which takes into account various aspects and mechanisms of interaction of cells of the immune system and NSC/NPC. The data on the immune response upon the transplantation of allo- and xenogeneic NSC/NPC and its dependence on the immune status of recipients are summarized. The relevance of studies of the immunobiological properties of neurogenic cells of the fetal brain that facilitate the discovery of mechanisms of action of NSC/NPC and an assessment of the possibility of their practical application for cell therapy of CNS lesions is emphasized.

Keywords: neurogenic stem cells, neurogenic progenitor cells, allotransplantation, xenotransplantation, immune response, immunomodulation.

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