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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 91-102


PROPERTIES OF VANILLOID RECEPTOR TYPE 1

M.O. Petrushenko, E.A. Petrushenko, E.A. Lukyanetz

    O.O. Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.091

Abstract

The review summarizes the current data on the functioning and characteristics of the vanilloid receptors of the transient potential of the TRPV1 type. Possible mechanisms of processes of sensitization and desentization of TRPV1 receptors, role of phosphorylation/dephosphorylation processes in channel activity, role of calcium/calmodulin dependent modulation, a role of phosphatidylinositol are indicated. Attention is paid to the structure of TRPV1 channels and the peculiarities of agonist and antagonist activity of these channels. The functions of these channels are described.

Keywords: TRPV1 receptors; TRPV1 channels; calcium; cationic channels; nociception; sensitization of receptors; desensitization of receptors.

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