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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 82-90

Nephroprotective properties of ATP-sensitive potassium channels agonist flocalin

A.І. Gozhenko1, N.D. Fіlipets2, O.O. Filipets2, O.A. Gozhenko1

  1. State Enterprise «Ukrainian Research Institute of Transport Medicine», Odessa, Ukraine
  2. Higher State Educational Institution «Bukovinian State Medical University», Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz64.01.082


Abstract

protection against ischemia and hypoxia, arousing an interest in search and study of the pharmacological activators of potassium current. Review is devoted to a generalized scientific literary data justifying a wide pharmacodynamical spectrum of flocalin – a potential drug from the class of KATP-channels activators with its features as a cardioprotector, myotropic spasmolytic, vasodilator and cerebroprotector. Results of own research showing the ability of flocalin to maintain homeostatic functions of kidneys under the conditions of water-salt loading are also represented. Taking into consideration cardiorenal continuum, pathogenetic connection between renal and cardiac pathology makes it possible to suggest an inhibitory influence of flocalin on the development of nephropathy. A prerequisite for a study of its renal effects is data concerning the mechanisms of correction the morphological, functional and biochemical pathological changes in myocardium by flocalin, which allows positioning this new activator of KATP-channels as a perspective cardioprotector and also may give rise to a new direction in nephroprotection.

Keywords: activator of ATP-sensitive potassium channels flocalin; pharmacodynamics; cardioprotection; nephroprotection.

Full text: (PDF, in English)

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