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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 73-81


CHANGES OF ULTRASTRUCTURE AND FUNCTIONAL ACTIVITY OF THE HYPOTHALAMUS IN TRAUMATIC OPTICAL NEUROPATHY

N.M. Moyseyenko

    Ivano-Frankivsk Medical University, Ivano-Frankivsk, Ukraine
DOI: https://doi.org/10.15407/fz64.01.073

Abstract

The ultrastructural changes and functional activity of the hypothalamus in traumatic optical neuropathy, which was with methylprednisolone at a dose of 30 mg/kg and 15 mg/kg in combination with phosphogenic stimulation with a current of 800 mA on the side of the defeat and 300 mA on the opposite side. According to our research, it has been established that traumatic damage to the orbital part of the optic nerve causes structural destructive changes in the suprachiasal nucleus of the hypothalamus in the form of hydrophobic and vacuoles dystrophy. It was found that the treatment contributed to the development of rejuvenating processes in the nucleus (more pronounced in combined treatment than in monotherapy with corticosteroids), changing its architectonics and increasing the number of neurosecretory granules. Reduced content of adrenocorticotropic hormone in the peripheral blood from 11,64±0,43 to 0,32±0,13 pg/ml (P<0,05) against the background of a sharp increase in the content of cortisol from 92,31±3,26 to 290,12±6,72 μg/dl (P<0,05) in monotherapy with methylprednisolone. When combined, the maintenance of hormones (6,13±0,12 pg/ml and 6,93±0,14 μg/dl, respectively) is closer to the group without treatment, and therefore, obviously, it is more physiological as it is endogenous processes of the organism. Consequently, contralateral phosphine electrostimulation leads to the activation of neurosecretory processes of the suprachioscular nucleus of the hypothalamus and normalization of the content of hormones.

Keywords: traumatic optic neuropathy; suprachiasmal nucleus of the hypothalamus; neurosecretory granules; phospheneelectrostimulation.

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