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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 66-72


ACID-BASED STATE OF BLOOD AND MIXTURE FOLDS IN RATS WITH PARODONTAL DISEASES

A.I. Bereznyakova, V.F. Cheremisina

    National Pharmaceutical University, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.066

Abstract

A comparative study of the dynamics of pH of blood and saliva of rats, as well as the concentration of calcium and inorganic phosphate in mixed saliva during test loading is carried out. A close correlation between the dynamics of the investigated parameters was found in both sugar and carbamide loading. The role of dismomeostasis of inorganic phosphate in the pathogenesis of periodontal inflammatory diseases is shown. The main diagnostic indicator of the violation of the acid-base state (COS) of blood and saliva of rats during periodontal diseases is the pH and excess or deficiency of the bases. With sugar loading, there is an accumulation of acidic equivalents, a decrease in the pH of the mixed saliva, the concentration of inorganic phosphate and an increase in calcium concentration. The most pronounced changes in rats with periodontitis, the smallest - in rats with alveolitis. At urea loading, the phosphate buffer system of saliva is involved, preferably, for correction of COS at pH values lower than 6.0. The decrease in the activity of phosphate secretion by salivary glands is due to the development of alkalosis in the oral cavity of rats. In the group of animals with gingivitis and alveolitis, the dynamics of the time dependence of the concentration of inorganic phosphate did not differ from the control, and in rats with periodontitis, the preventive character of the stabilization of the concentration of inorganic phosphate compared with the pH was found.

Keywords: acid-alkaline state; pH; gingivitis; alveolitis; periodontitis; test loads; rats

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