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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 59-65


Pathophysiological role of incomplete body adaptation and overactivation response reaction in diseases of internal organs

Z.M. Kit

    Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.059

Abstract

The introduction of new approaches to determine the patient’s condition and treatment efficacy is feasible only with adaptation responses, among which the incomplete adaptation and overactivation occupy an important place. The study of adaptation processes by adaptation index, relative content of blood lymphocytes, type of adaptation and state of its mechanisms was conducted in 1208 patients. Incomplete adaptation with flaccid inflammatory syndrome was detected in 15±4% of the set (3-30%); with a high prevalence among patients with indices of digestive (5-30%) and endocrine (3-28%) systems. An increase in its frequency after treatment of liver diseases (from 34% to 45%) may indicate an unfavorable prognosis. The frequency of detection of the overactivation reaction ranged from 0 to 12%, and it also occurred more often among gastroenterological patients (about 4%). Internal diseases had some peculiarities in these reactions: lower parameters of the function of external respiration were diagnosed in patients with bronchoconstriction; the adaptation index correlated with the main parameters of hemodynamics in cardiovascular patients; functional parameters were worse at a lower level of reactivity with changes in WBC differential in patients with chronic kidney disease. Reactions of incomplete adaptation and overactivation relate to distress and correlate with the course of inflammation, hemostasis and immune reactivity; determine severer course of the disease and functional changes in the remission stage.

Keywords: non-specific adaptive responses to stress; reactions adaptation; reactions overactivation.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2020.