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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2018; 64(1): 34-39


VARIOUS POLYPHENOLS IMPACT ON DISTURBANCE OF CHOLESTEROL METABOLISM UNDER INSULIN RESISTANCE

V.P. Fylymonenko, A.L. Zagayko

    National University of Pharmacy, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz64.01.034

Abstract

Effect of quercetin, epigallocatechin gallate and polyphenol extract from grapes administration on the changes in cholesterol metabolism in the rat blood serum under insulin resistance was studied. The development of atherogenic dyslipoproteinemia has been revealed: the accumulation of total cholesterol (2.12 times) due to the increase of very low density lipoproteins cholesterol content (1.75 times), the decrease of high density lipoproteins cholesterol concentration (2.6 times) and the increase of the atherogenic index (8.8 times) in animals on a high-fructose diet. The use of all studied polyphenols normalized the indicators of cholesterol metabolism in a different degree. Polyphenolic grape extract showed more pronounced protective properties, obviously due to the variety of composition and, accordingly, the mechanisms of insulin resistance correction.

Keywords: insulin resistance; cholesterol metabolism; grape polyphenols; quercetin; epigallocatechin gallate.

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